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Keywords: AMPK
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Essays Biochem (2024) EBC20240003.
Published: 25 September 2024
... of morbidity and mortality worldwide. In recent years, considerable attention has been directed toward understanding the molecular mechanisms underlying HF pathogenesis, with a particular focus on the role of AMP-activated protein kinase (AMPK) and protein O-GlcNAcylation. This review comprehensively examines...
Articles
Essays Biochem (2024) EBC20240011.
Published: 13 September 2024
... as an important junction point that connects Ca 2+ signaling with energy metabolism. By activating the metabolic regulator AMP-activated protein kinase (AMPK), CaMKK2 integrates Ca 2+ signals with cellular energy status, enabling the synchronization of cellular activities regulated by Ca 2+ with energy...
Articles
Essays Biochem (2024) EBC20240006.
Published: 28 August 2024
...Barnaby P. Frankish; Robyn M. Murphy Since its discovery over five decades ago, an emphasis on better understanding the structure and functional role of AMPK has been prevalent. In that time, the role of AMPK as a heterotrimeric enzyme that senses the energy state of various cell types has been...
Articles
Essays Biochem (2024) EBC20240008.
Published: 23 August 2024
... in adipose tissue lipid metabolism, and its apparent inhibition of adipogenesis. However, recent studies utilising AMP-activated protein kinase (AMPK)-specific compounds highlight a more subtle, time-dependent role for AMPK in the process of adipogenesis, and in a previously unexplored repression of leptin...
Articles
Essays Biochem (2024) EBC20240009.
Published: 26 July 2024
...Mark H. Rider; Didier Vertommen; Manuel Johanns AMP-activated protein kinase (AMPK) is a key regulator of metabolism and a recognised target for the treatment of metabolic diseases such as Type 2 diabetes (T2D). Here, we review how mass spectrometry (MS) can be used to study short-term control...
Articles
Essays Biochem (2024) EBC20240007.
Published: 12 July 2024
...William J. Smiles; Ashley J. Ovens; Bruce E. Kemp; Sandra Galic; Janni Petersen; Jonathan S. Oakhill Metabolic homeostasis and the ability to link energy supply to demand are essential requirements for all living cells to grow and proliferate. Key to metabolic homeostasis in all eukaryotes are AMPK...
Articles
Essays Biochem (2017) 61 (6): 699–710.
Published: 12 December 2017
... 2017 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2017 autophagy AMPK cancer ER stress mTOR ULK1 Mechanistic target of rapamycin (mTOR) complex 1 (mTORC1) senses and integrates a variety of inputs, including growth signals, amino acid levels...
Articles
Essays Biochem (2013) 55: 119–131.
Published: 27 September 2013
... in our ‘ageing’ world. 1 To whom correspondence should be addressed (email [email protected] ). © The Authors Journal compilation © 2013 Biochemical Society 2013 AMPK inflammation mTOR neurodegeneration protein aggregation ROS cellular senescence Autophagy...
Articles
Essays Biochem (2013) 55: 1–15.
Published: 27 September 2013
... pathways that interconnect with the core mTORC1–ULK1 signalling module. 1 To whom correspondence should be addressed (email [email protected] ). © The Authors Journal compilation © 2013 Biochemical Society 2013 amino-acid starvation AMPK ATG1 ATG13 ATG17 FIP200 mTORC1 PAS...