... into weakly structured species, weak (or fast cycling) binding interactions, and subtle shifts in conformational dynamics. This includes intrinsically disordered proteins and regions (IDPs/IDRs) that are associated with cancer and amyloidotic neurodegenerative disease. For nucleic acids and carbohydrates...

... University Press. ( B ) The functional cycle of dihydrofolate reductase (DHFR) directly observed by electro-osmotic trapping in the ClyA protein pore sensor resolves five functional states (four displayed) [ 103 ]. Re-printed with permission from the authors. Conformational dynamics Nanopores...

...). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Conformational Dynamics FRET Nucleic Acids Proteins Simulations Single-Molecule The ability...