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Keywords: DNA repair
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Articles
Essays Biochem (2021) 65 (1): 17–26.
Published: 16 April 2021
...Dominika Gruszka; George Cameron; Hasan Yardimci Cell-free extracts from Xenopus laevis eggs are a model system for studying chromosome biology. Xenopus egg extracts can be synchronised in different cell cycle stages, making them useful for studying DNA replication, DNA repair and chromosome...
Articles
Essays Biochem (2020) 64 (5): 683–685.
Published: 23 October 2020
... © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 cancer DNA damage response DNA Repair Maintaining the genome stability is a challenge, but essential task for cells. DNA damage, caused by both endogenous and exogenous sources, triggers...
Articles
Essays Biochem (2020) 64 (5): 831–843.
Published: 10 July 2020
... DNA repair Base excision repair is a highly conserved mechanism dealing with oxidative damage generated by respiration, natural hydrolysis and alkylation reactions that occur in each cell, many thousands of times a day [ 1 ]. In humans at least 30 proteins are involved in both short patch...
Articles
Essays Biochem (2020) 64 (5): 737–752.
Published: 26 May 2020
.... Schmidt ( christine.schmidt@manchester.ac.uk ) 16 03 2020 20 04 2020 01 05 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 DNA damage response (DDR) DNA repair FAT10 ISG15 Ubiquitin-like proteins (UBLs) UBL5 UFM1...
Articles
Essays Biochem (2020) 64 (5): 705–719.
Published: 20 April 2020
... to permit faithful DNA repair, failing of which leads to elevated chromosomal aberrations and cell hypersensitivity to DNA damage. Here, we summarize the molecular bases for transcriptional control during DSB metabolism, and discuss how the exquisite coordination between the two DNA-templated processes may...
Articles
Essays Biochem (2019) 63 (5): 569–577.
Published: 31 July 2019
... and envelope. Both processes mislocalize diffusible nuclear factors including key DNA repair and regulatory proteins. Importantly, these effects of constricted migration are accompanied by excess DNA damage, marked by phosphorylated histone γH2AX in fixed cells. Rupture has a number of downstream consequences...
Articles
Essays Biochem (2017) 61 (3): 305–315.
Published: 26 May 2017
... ( jan.vijg@einstein.yu.edu ) 22 02 2017 18 04 2017 02 05 2017 © 2017 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2017 ageing DNA mutation DNA repair Somatic mutation As the carrier of genetic information, DNA is a very stable...
Articles
Essays Biochem (2015) 58: 101–113.
Published: 15 September 2015
... the scope of SA functions beyond plant immunity to include plant growth and development, endoplasmic reticulum (ER) stress, DNA repair and homologous recombination. Finally, we shed light on the roles of SA in epigenetically controlled transgenerational immune memory that has long-term benefits for plants...