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Keywords: Dna damage
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Essays Biochem (2020) 64 (5): 819–830.
Published: 23 October 2020
... Commons Attribution License 4.0 (CC BY) . Open access for this article was enabled by the participation of University of Oxford in an all-inclusive Read & Publish pilot with Portland Press and the Biochemical Society under a transformative agreement with JISC. DNA damage DNA synthesis...
Essays Biochem (2020) 64 (5): 753–764.
Published: 26 August 2020
...Kate M. MacDonald; Soraya Benguerfi; Shane M. Harding Healthy cells experience thousands of DNA lesions per day during normal cellular metabolism, and ionizing radiation and chemotherapeutic drugs rely on DNA damage to kill cancer cells. In response to such lesions, the DNA damage response (DDR...
Essays Biochem (2020) 64 (5): 687–703.
Published: 18 August 2020
...Anusha Sriraman; Turja K. Debnath; Blerta Xhemalce; Kyle M. Miller Cells encounter a multitude of external and internal stress-causing agents that can ultimately lead to DNA damage, mutations and disease. A cascade of signaling events counters these challenges to DNA, which is termed as the DNA...
Essays Biochem (2020) 64 (5): 831–843.
Published: 10 July 2020
... are generated as intermediates during the repair process. While deficiencies in BER activity can lead to high mutation rates and tumorigenesis, cancer cells often rely on increased BER activity to tolerate oxidative stress. Targeting BER has been an attractive strategy to overwhelm cancer cells with DNA damage...
Essays Biochem (2020) 64 (5): 721–735.
Published: 03 July 2020
...Ruth F. Ketley; Monika Gullerova The mechanisms by which RNA acts in the DNA damage response (DDR), specifically in the repair of DNA double-strand breaks (DSBs), are emerging as multifaceted and complex. Different RNA species, including but not limited to; microRNA (miRNA), long non-coding RNA...
Essays Biochem (2020) 64 (5): 705–719.
Published: 20 April 2020
... to permit faithful DNA repair, failing of which leads to elevated chromosomal aberrations and cell hypersensitivity to DNA damage. Here, we summarize the molecular bases for transcriptional control during DSB metabolism, and discuss how the exquisite coordination between the two DNA-templated processes may...