... agreement with JISC. DNA damage DNA synthesis and repair protein structure synthetic lethality Figure 2 Structures of RecQ helicases ( A ) Structures of the five human RecQ family members RECQL1 [ 43 ], BLM [ 46 ], WRN [ 49 ], RECQL4 [ 48 ] and RECQL5 [ 47 ] viewed from the same...

...Kate M. MacDonald; Soraya Benguerfi; Shane M. Harding Healthy cells experience thousands of DNA lesions per day during normal cellular metabolism, and ionizing radiation and chemotherapeutic drugs rely on DNA damage to kill cancer cells. In response to such lesions, the DNA damage response (DDR...

...Anusha Sriraman; Turja K. Debnath; Blerta Xhemalce; Kyle M. Miller Cells encounter a multitude of external and internal stress-causing agents that can ultimately lead to DNA damage, mutations and disease. A cascade of signaling events counters these challenges to DNA, which is termed as the DNA...

... are generated as intermediates during the repair process. While deficiencies in BER activity can lead to high mutation rates and tumorigenesis, cancer cells often rely on increased BER activity to tolerate oxidative stress. Targeting BER has been an attractive strategy to overwhelm cancer cells with DNA damage...

...Ruth F. Ketley; Monika Gullerova The mechanisms by which RNA acts in the DNA damage response (DDR), specifically in the repair of DNA double-strand breaks (DSBs), are emerging as multifaceted and complex. Different RNA species, including but not limited to; microRNA (miRNA), long non-coding RNA...

... to permit faithful DNA repair, failing of which leads to elevated chromosomal aberrations and cell hypersensitivity to DNA damage. Here, we summarize the molecular bases for transcriptional control during DSB metabolism, and discuss how the exquisite coordination between the two DNA-templated processes may...