..., the emerging clinical multidrug resistance (MDR) has become a matter of grave concern for medical professionals. Despite advances in therapeutic interventions, it has not yet been possible to devise convincing strategies to combat antifungal resistance. Comprehensive understanding of the molecular mechanisms...

... 01 2017 24 01 2017 © 2017 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2017 Antimicrobial resistance membrane transport protein multidrug resistance Figure 1 Schematic illustration of the seven families/superfamilies...

... and/or hinder any of the transport-dependent steps of the pump. In this review, we provide an overview of multidrug-resistance EPs, their inhibition strategies and the relevant findings from the various computational simulation studies reported to date with respect to deciphering the mechanism of action...