..., however, are fragile to the specific removal of hubs [ 50 , 59 , 61 ]. biological networks bioinformatics computational biology computational models personalized medicine Systems Biology In a bottom-up approach, cellular and molecular components are studied as parts of a system...

... of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . biological networks intracellular signaling phosphorylation/dephosphorylation systems biology Cells transduce and integrate environmental stimuli through a variety of intracellular signalling...

... ) * These authors contributed equally to this work. 20 03 2017 16 05 2017 17 05 2017 Figure 2 Lifespan extending interventions promote maintenance of biological networks into old age Solid lines indicate intact connections, and dashed lines represent lost connections. ageing...