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Keywords: breast cancers
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Essays Biochem (2021) EBC20200174.
Published: 30 July 2021
...Corinne N. Haines; Suzanne E. Wardell; Donald P. McDonnell Nearly 80% of all breast cancers are estrogen receptor positive (ER+) and require the activity of this transcription factor for tumor growth and survival. Thus, endocrine therapies, which target the estrogen signaling axis, have and will...
Essays Biochem (2021) EBC20200165.
Published: 16 June 2021
...Carlos Perez Kerkvliet; Thu H. Truong; Julie Hanson Ostrander; Carol A. Lange The classification and treatment of breast cancer is largely defined by the expression of steroid hormone receptors (HRs), namely estrogen receptor (ER) and progesterone receptor (PR), and gene amplification...
Essays Biochem (2021) EBC20200163.
Published: 01 June 2021
...Sebastian Giulianelli; Caroline A. Lamb; Claudia Lanari Progesterone receptors (PR) play a pivotal role in many female reproductive tissues such as the uterus, the ovary, and the mammary gland (MG). Moreover, PR play a key role in breast cancer growth and progression. This has led to the...