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Keywords: drug discovery and design
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Articles
Essays Biochem (2024) EBC20230081.
Published: 31 May 2024
... potential for clinical applications. Correspondence: Sarah A. Wacker ( [email protected] ) 04 03 2024 15 05 2024 17 05 2024 © 2024 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2024 drug discovery and design malate...
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Essays Biochem (2017) 61 (5): 453–464.
Published: 08 November 2017
... screening, generating a model for fragment binding and fragment to lead optimization – are described in the sections that follow. chemical biology drug discovery and design fragment based lead discovery The key feature of fragment methods is that discovery begins by identification of low...
Articles
Essays Biochem (2017) 61 (5): 431–437.
Published: 08 November 2017
... 2017 17 10 2017 18 10 2017 © 2017 The Author(s). 2017 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . drug discovery and design pharmacology...
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Essays Biochem (2017) 61 (5): 475–484.
Published: 08 November 2017
... fragments, and benefits from only requiring small amounts of target protein; however, it is also susceptible to nonspecific binding at high concentration, which can result in false positives. crystallography drug discovery and design protein-protein interactions The discovery of new small...
Articles
Essays Biochem (2017) 61 (5): 529–542.
Published: 08 November 2017
...). © 2017 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2017 drug discovery and design membrane proteins Room temperature crystallography Serial crystallography X-ray Free Electron Laser X-ray free electron lasers (XFELs) have transformed from...
Articles
Essays Biochem (2017) 61 (1): 103–114.
Published: 03 March 2017
... infections drug discovery and design Gram negative bacteria Gram positive bacteria Antibiotics have saved more lives than any other class of drugs. Yet they are misused, undervalued and now endangered by the rise of extremely resistant bacteria that cannot be treated with our current apothecary...