... advances in research on the molecular, biochemical and epigenetic drivers of plant immune priming. We review recent findings about the perception and signalling mechanisms controlling the onset of priming by the plant stress metabolite β-aminobutyric acid. In addition, we review the evidence for epigenetic...

... in splicing, processing and modification of RNA. In addition to these ‘housekeeping’ ncRNAs, regulatory ncRNAs like microRNAs (miRNAs) modulate gene expression at the post-transcriptional level [ 4 ]. Moreover, chromatin-associated ncRNAs are involved in epigenetic gene regulation [ 5 , 6 ]. epigenetics...

... types in the human body. The great variation in structure and function displayed by cells with identical genetic background is attributed to additional genomic information content. This includes large-scale genetic aberrations, as well as diverse epigenetic patterns that are crucial for regulating...

.... This review focuses on our current understanding of DNA methylation in maintaining genome integrity in mammalian cells. DNA methylation is a reversible epigenetic mark, which has been implicated in DNA damage signaling, repair and replication. Sites of DNA methylation can trigger mutations, which are drivers...

... their faithful inheritance, and transfer from cell culture to animal model systems. These advances have contributed to advancements in synthetic biology, biomedical research, and applications in industry and in the clinic. artificial chromosome cellular reproduction centromere chromosomes epigenetics...

...Ksenia Skvortsova; Clare Stirzaker; Phillippa Taberlay As one of the most abundant and well-studied epigenetic modifications, DNA methylation plays an essential role in normal development and cellular biology. Global alterations to the DNA methylation landscape contribute to alterations...

... that epigenetic mechanisms are involved in the cellular memory of these expression states. Among these, methylation of CpG sites on DNA is one of the best described modification to explain somatic inheritance. Here, we discuss the relevance of DNA methylation for the establishment and maintenance of monoallelic...

...Quentin Gouil; Andrew Keniry Bisulfite sequencing is a powerful technique to detect 5-methylcytosine in DNA that has immensely contributed to our understanding of epigenetic regulation in plants and animals. Meanwhile, research on other base modifications, including 6-methyladenine and 4...

... of the Biochemical Society 2019 Figure 3 Summary of targeted DNA methylation editing technologies available Figure created with BioRender.com Correspondence: Ryan Lister ( [email protected] ) 19 09 2019 23 10 2019 24 10 2019 CRISPR epigenetics epigenome...

... 4.0 (CC BY-NC-ND) . chromatin epigenetics epigenomics methylation plant biology Methylation of cytosines is a widespread modification of DNA and is found across both eukaryotes [ 1 , 2 ] and prokaryotes [ 3 ]. Because it is a modification of DNA itself, it can persist through both...

... for equal segregation of chromosomes. The centromere is characterized by both protein and DNA elements: the histone H3 variant CENP-A epigenetically defines the location of the centromere while centromeric DNA sequences are neither necessary nor sufficient for centromere function. Paradoxically, the DNA...

... has reverted. Such transgenerational epigenetic inheritance requires that information be stored in the germline in response to exogenous stressors. One of the most elusive questions in the field of epigenetic inheritance is the identity of such inherited factor(s). Answering this question would allow...