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Keywords: estrogen
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Essays Biochem (2021) EBC20200175.
Published: 22 June 2021
...Seoung-Ae Lee; Seunghan Baik; Sang-Hyuk Chung There has been little progress for several decades in modalities to treat cervical cancer. While the cervix is a hormone-sensitive tissue, physiologic roles of estrogen receptor α (ERα), progesterone receptor (PR), and their ligands in this tissue are...
Essays Biochem (2021) EBC20210019.
Published: 01 June 2021
... review the insights we learned from cryoEM studies of the estrogen and androgen receptor transcriptional complexes. Despite similar domain organizations, the two receptors have different coregulator interaction modes. The cryoEM structures now have revealed the fundamental differences between the two...