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Keyword: extracellular matrix
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Essays Biochem (2019) 63 (5): 497-508.
Published: 24 September 2019
... Biochemical Society 2019 cellular plasticity extracellular matrix myosin II Migration is a fundamental behavior of cells found in all multicellular organisms from sponges to vertebrates. During development, regeneration, normal physiology and disease, cells travel short or long distances...
Essays Biochem (2019) 63 (3): 349-364.
Published: 05 September 2019
...-binding site. They catalyze the first step of the covalent cross-linking of the extracellular matrix (ECM) proteins collagens and elastin, which contribute to ECM stiffness and mechanical properties. The role of LOX and LOXL2 in fibrosis, tumorigenesis, and metastasis, including changes in their...
Essays Biochem (2019) 63 (3): 417-432.
Published: 28 August 2019
...Isra N. Taha; Alexandra Naba The extracellular matrix (ECM) is a complex assembly of hundreds of proteins that constitutes the scaffold of multicellular organisms. In addition to providing architectural and mechanical support to the surrounding cells, it conveys biochemical signals that regulate...
Essays Biochem (2019) 63 (3): 407-416.
Published: 28 August 2019
...Bruno Gideon Bergheim; Suat Özbek Cnidarians, members of an early-branching metazoan phylum, possess an extracellular matrix (ECM) between their two epithelial cell layers, called the mesoglea. The cnidarian ECM, which is best studied in Hydra , contains matrix components reflective of both...
Essays Biochem (2019) 63 (5): 535-551.
Published: 23 August 2019
... signalling cascades, mechanosensing and reciprocal feedback to the extracellular environment. We also discuss the role of IACs in extracellular matrix remodeling and how they impact upon cell migration. Figure 3 Integrin signalling and activation ( A ) Schematic representation of integrins at the...
Essays Biochem (2019) 63 (3): 297-312.
Published: 06 August 2019
...Anna Gatseva; Yuan Yan Sin; Gaia Brezzo; Tom Van Agtmael Basement membranes (BMs) are specialised extracellular matrix (ECM) structures and collagens are a key component required for BM function. While collagen IV is the major BM collagen, collagens VI, VII, XV, XVII and XVIII are also present...
Essays Biochem (2019) 63 (3): 325-335.
Published: 26 July 2019
... regulation of collagen hydroxylation may have remarkable effects on the properties of the extracellular matrix and consequently on the cell behaviour. Correspondence: Jyrki Heino ( jyrki.heino@utu.fi ) 28 05 2019 25 06 2019 01 07 2019 © 2019 The Author(s). 2019 This is an open...
Essays Biochem (2019) 63 (3): 337-348.
Published: 02 July 2019
...Richard W. Farndale The Collagen Toolkits are libraries of 56 and 57 triple-helical synthetic peptides spanning the length of the collagen II and collagen III helices. These have been used in solid-phase binding assays to locate sites where collagen receptors and extracellular matrix components...
Essays Biochem (2019) 63 (3): 313-323.
Published: 26 June 2019
... J.S. Hulmes ( david.hulmes@ibcp.fr ) 03 04 2019 01 06 2019 04 06 2019 © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 biosynthesis collagen extracellular matrix Collagens are the most abundant proteins in...
Essays Biochem (2019) 63 (3): 285-295.
Published: 15 May 2019
... License 4.0 (CC BY) . cell adhesion crystallography extracellular matrix About 40 years ago, two laboratories independently purified a large glycoprotein from the extracellular matrix produced by mouse tumour cells [ 1 , 2 ]. Antibodies raised against this glycoprotein reacted with...
Essays Biochem (2018) 62 (4): 607-617.
Published: 23 August 2018
... Biochemical Society 2018 extracellular matrix heterocellular proteolysis systems biology spatial regulation wound healing A primary driver of systems biology is to understand how biological components are organized into networks and to discern the patterns of these interactions giving rise...