... of LRRK2 signaling in neurodegeneration. Correspondence: Elisa Greggio ( [email protected] ) 26 08 2021 13 11 2021 23 11 2021 © 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 cytoskeleton glia inflammation kinase...

... ) 28 04 2021 12 07 2021 15 07 2021 © 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 immunometabolism inflammation macrophages NR4A1 nuclear receptors The nuclear receptor Nur77 (also known as NR4A1, NGFI-B, TR3...

... on this information, the E 2 -induced activity of ER appears to be an essential mediator of intestinal inflammation. Related, expression and activity of ERβ are reduced in the colonic mucosa of patients with IBDs during active disease compared to non-inflamed tissue [ 41 ]. Although ERβ is considered the dominant...

...Nan Chiang; Charles N. Serhan Today, persistent and uncontrolled inflammation is appreciated to play a pivotal role in many diseases, such as cardiovascular diseases, neurodegenerative diseases, metabolic syndrome and many other diseases of public health concern (e.g. Coronavirus Disease 2019...

.... Because they are rapidly catabolised, eicosanoids mainly act locally to the site of their production. Many eicosanoids have multiple, sometimes pleiotropic, effects on inflammation and immunity. The most widely studied is PGE 2 . Many eicosanoids have roles in the regulation of the vascular, renal...

..., or organogenesis. Furthermore, some bioactive sphingolipids are implicated in pathological processes including inflammation-associated illnesses such as atherosclerosis, rheumatoid arthritis, inflammatory bowel disease (namely Crohn’s disease and ulcerative colitis), type II diabetes, obesity, and cancer. A major...

... increase cell proliferation, migration, survival and angiogenesis. Acute inflammation produced by tissue damage stimulates ATX production and LPA signalling as a component of wound healing. If inflammation does not resolve, LPA signalling becomes maladaptive in conditions including arthritis, neurologic...

... Press Limited on behalf of the Biochemical Society 2020 hypochlorous acid inflammation myeloperoxidase oxidative stress Mammalian heme peroxidases are a family of enzymes that play a key role in the destruction of bacteria and invading pathogens in the innate immune response [ 1 , 2...

... on behalf of the Biochemical Society 2017 autophagy amphisome cellular secretion inflammation lysosome mitochondria The standard mode of secretion for proteins is the conventional secretory pathway. These proteins possess at their N-terminus a leader peptide (or signal peptide), which...

... in our ‘ageing’ world. 1 To whom correspondence should be addressed (email [email protected] ). © The Authors Journal compilation © 2013 Biochemical Society 2013 AMPK inflammation mTOR neurodegeneration protein aggregation ROS cellular senescence Autophagy...