... into weakly structured species, weak (or fast cycling) binding interactions, and subtle shifts in conformational dynamics. This includes intrinsically disordered proteins and regions (IDPs/IDRs) that are associated with cancer and amyloidotic neurodegenerative disease. For nucleic acids and carbohydrates...

...Samrat Mukhopadhyay; Jasmine Cubuk; Melissa D. Stuchell-Brereton; Andrea Soranno Intrinsically disordered proteins (IDPs) and regions (IDRs) have emerged as key players across many biological functions and diseases. Differently from structured proteins, disordered proteins lack stable structure...

...Samrat Mukhopadhyay; Samrat Mukhopadhyay Intrinsically disordered proteins (IDPs) defy the conventional structure–function paradigm and do not autonomously fold up into unique 3D structures for carrying out functions. They exist as rapidly interconverting conformational ensembles and are thought...

.... Correspondence: Sonia Longhi ( [email protected] ) 30 06 2022 18 08 2022 25 08 2022 © 2022 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2022 amyloid intrinsically disordered proteins liquid-liquid phase separations paramyxoviruses...

...Samrat Mukhopadhyay; Kurtis Mengham; Youssra Al-Hilaly; Sebastian Oakley; Kamillia Kasbi; Mahmoud B. Maina; Louise C. Serpell Tau is an intrinsically disordered protein that has the ability to self-assemble to form paired helical and straight filaments in Alzheimer’s disease, as well as the ability...

...Samrat Mukhopadhyay; Estella A. Newcombe; Elise Delaforge; Rasmus Hartmann-Petersen; Karen Skriver; Birthe B. Kragelund Phosphorylation is the most common post-translational modification (PTM) in eukaryotes, occurring particularly frequently in intrinsically disordered proteins (IDPs...

... to facilitate controlled changes in cellular processes were initially explained by stable structure within interfaces and complexes between binding partners [ 1 ]. However, it has become increasingly clear that many cellular processes are governed by complexes involving intrinsically disordered proteins/regions...

... complex IDP intrinsically disordered protein KMN KNL1, Mis12 complex, and Ndc80 complex kMT kinetochore–microtubule KT kinetochore MCC mitotic checkpoint complex MT microtubule PF protofilament PP1 protein phosphatase 1 PP2A protein phosphatase 2A...

... A. Volkov ( [email protected] ) 05 03 2020 01 05 2020 14 05 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 force intrinsically disordered proteins kinetochores microtubule In this review, I focus...

..., dynamic and liquid-like assembly is emerging, in which intrinsically disordered proteins (IDPs) and proteins containing intrinsically disordered regions (IDRs) play a central role. Disorder features at all levels of chromatin organisation, from the histone tails, which are sites of extensive post...