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Keywords: kinetochores
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Articles
Essays Biochem (2020) 64 (2): 337–347.
Published: 26 August 2020
...Amit Rahi; Manas Chakraborty; Kristen Vosberg; Dileep Varma The faithful segregation of duplicated sister chromatids rely on the remarkable ability of kinetochores to sustain stable load bearing attachments with the dynamic plus ends of kinetochore–microtubules (kMTs). The outer layer...
Articles
Essays Biochem (2020) 64 (2): 233–249.
Published: 05 August 2020
... stability. The centromere is the unique chromosomal region that assembles the kinetochore and connects to microtubules to orchestrate chromosome movement during cell division. While monocentromeres are the most commonly characterized centromere organization found in studied organisms, diffused...
Articles
Essays Biochem (2020) 64 (2): 349–358.
Published: 05 August 2020
...Margaux R. Audett; Thomas J. Maresca The kinetochore (KT) field has matured tremendously since Earnshaw first identified CENP-A, CENP-B, and CENP-C [ 1 , 2 ]. In the past 35 years, the accumulation of knowledge has included: defining the parts list, identifying epistatic networks of interdependence...
Articles
Essays Biochem (2020) 64 (2): 371–382.
Published: 05 June 2020
... A. Volkov ( v.volkov@tudelft.nl ) 05 03 2020 01 05 2020 14 05 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 force intrinsically disordered proteins kinetochores microtubule Cells actively rearrange themselves...
Articles
Essays Biochem (2020) 64 (2): 277–287.
Published: 14 May 2020
...Gisela Cairo; Soni Lacefield Faithful chromosome segregation in mitosis and meiosis requires that chromosomes properly attach to spindle microtubules. Initial kinetochore-microtubule attachments are often incorrect and rely on error correction mechanisms to release improper attachments, allowing...
Articles
Essays Biochem (2020) 64 (2): 299–311.
Published: 14 May 2020
...Amanda J. Broad; Jennifer G. DeLuca The fidelity of chromosome segregation during mitosis is intimately linked to the function of kinetochores, which are large protein complexes assembled at sites of centromeric heterochromatin on mitotic chromosomes. These key “orchestrators” of mitosis physically...