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Keywords: malate dehydrogenase
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Essays Biochem (2024) EBC20230080.
Published: 12 July 2024
... to respond quickly to different environments, energy states, and stresses. Malate dehydrogenase (MDH) is a metabolic enzyme that is conserved in all domains of life and is extensively modified post-translationally. Due to the central role of MDH, its modification can alter metabolic flux, including the Krebs...
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Essays Biochem (2024) EBC20230077.
Published: 26 June 2024
... production occurs through the promiscuous activities of malate dehydrogenase (MDH) and lactate dehydrogenase (LDH) under acidic and/or hypoxic conditions. D-2HG frequently accumulates by gain-of-function mutations in the genes encoding two isoforms of isocitrate dehydrogenase ( IDH1 and IDH2 ). Cognate...
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Essays Biochem (2024) EBC20230089.
Published: 13 June 2024
...Lisa M. Baird; Christopher E. Berndsen; Jonathan D. Monroe Malate dehydrogenase (MDH) catalyzes the interconversion of oxaloacetate and malate coupled to the oxidation/reduction of coenzymes NAD(P)H/NAD(P) + . While most animals have two isoforms of MDH located in the cytosol and mitochondria, all...
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Essays Biochem (2024) EBC20230081.
Published: 31 May 2024
...Charles S. Fermaintt; Sarah A. Wacker Malate dehydrogenase (MDH) enzymes play critical roles in cellular metabolism, facilitating the reversible conversion of malate to oxaloacetate using NAD + /NADH as a cofactor. The two human isoforms of MDH have roles in the citric acid cycle and the malate...
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Essays Biochem (2024) EBC20230086.
Published: 09 May 2024
...Laura de Lorenzo; Tyler M.M. Stack; Kristin M. Fox; Katherine M. Walstrom Malate dehydrogenase (MDH) is a ubiquitous and central enzyme in cellular metabolism, found in all kingdoms of life, where it plays vital roles in the cytoplasm and various organelles. It catalyzes the reversible NAD...