...Laura de Lorenzo; Tyler M.M. Stack; Kristin M. Fox; Katherine M. Walstrom Malate dehydrogenase (MDH) is a ubiquitous and central enzyme in cellular metabolism, found in all kingdoms of life, where it plays vital roles in the cytoplasm and various organelles. It catalyzes the reversible NAD...

...Charles S. Fermaintt; Sarah A. Wacker Malate dehydrogenase (MDH) enzymes play critical roles in cellular metabolism, facilitating the reversible conversion of malate to oxaloacetate using NAD + /NADH as a cofactor. The two human isoforms of MDH have roles in the citric acid cycle and the malate...

...Joseph J. Provost; Kathleen A Cornely; Pamela S. Mertz; Celeste N. Peterson; Sophie G. Riley; Harrison J. Tarbox; Shree R. Narasimhan; Andrew J Pulido; Amy L. Springer Malate dehydrogenase (MDH) is a key enzyme in mammalian metabolic pathways in cytosolic and mitochondrial compartments. Regulation...

...Betsy Leverett; Shane Austin; Jason Tan-Arroyo Malate dehydrogenase (MDH) is an essential enzyme in the tricarboxylic acid cycle that functions in cellular respiration and redox homeostasis. Recent studies indicate that MDH facilitates metabolic plasticity in tumor cells, catalyzing the formation...

...Joseph J. Provost; Amy D. Parente; Kristin M. Slade; Thomas J. Wiese In this review, we examine the protein–protein interactions of cytosolic malate dehydrogenase (MDH), an under-studied area in cellular metabolism. We provide a comprehensive overview of MDH involvement in metabolism, especially...

...Lisa M. Baird; Christopher E. Berndsen; Jonathan D. Monroe Malate dehydrogenase (MDH) catalyzes the interconversion of oxaloacetate and malate coupled to the oxidation/reduction of coenzymes NAD(P)H/NAD(P) + . While most animals have two isoforms of MDH located in the cytosol and mitochondria, all...

... production occurs through the promiscuous activities of malate dehydrogenase (MDH) and lactate dehydrogenase (LDH) under acidic and/or hypoxic conditions. D-2HG frequently accumulates by gain-of-function mutations in the genes encoding two isoforms of isocitrate dehydrogenase ( IDH1 and IDH2 ). Cognate...

...Joy Omini; Taiwo Dele-Osibanjo; Heejeong Kim; Jing Zhang; Toshihiro Obata This review discusses the intriguing yet controversial concept of metabolons, focusing on the malate dehydrogenase-citrate synthase (MDH-CISY) metabolon as a model. Metabolons are multienzyme complexes composed of enzymes...

...Amy D. Parente; Danielle E. Bolland; Kathryn L. Huisinga; Joseph J. Provost Malate dehydrogenase (MDH) is pivotal in mammalian tissue metabolism, participating in various pathways beyond its classical roles and highlighting its adaptability to cellular demands. This enzyme is involved...

... to respond quickly to different environments, energy states, and stresses. Malate dehydrogenase (MDH) is a metabolic enzyme that is conserved in all domains of life and is extensively modified post-translationally. Due to the central role of MDH, its modification can alter metabolic flux, including the Krebs...

..., course-based undergraduate research experiences (CUREs) expand the number of students who participate in research and provide benefits similar to faculty-mentored research. Instructors also benefit from teaching CUREs. Using a systematic review of 14 manuscripts concerning the Malate Dehydrogenase CUREs...