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Keywords: mass spectrometry
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Essays Biochem (2023) 67 (6): 957–965.
Published: 28 September 2023
...Ben Nicholas; Paul Skipp Immunopeptidomics is the survey of all peptides displayed on a cell or tissue when bound to human leukocyte antigen (HLA) molecules using tandem mass spectrometry. When attempting to determine the targets of tumour-specific CD8+ T cells, a survey of the potential ligands...
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Essays Biochem (2023) 67 (2): 283–300.
Published: 29 March 2023
...Tanja Habeck; Frederik Lermyte Top-down protein mass spectrometry can provide unique insights into protein sequence and structure, including precise proteoform identification and study of protein–ligand and protein–protein interactions. In contrast with the commonly applied bottom-up approach, top...
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Essays Biochem (2023) 67 (2): 255–267.
Published: 29 March 2023
... owing to their hydrophobic character and relationship with their compositionally complex lipid environment. Advances in structural mass spectrometry (MS) techniques have made it possible to study these systems to elucidate critical information on their structure–function relationships. For example, MS...
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Essays Biochem (2023) 67 (2): 269–282.
Published: 29 March 2023
... cyanobacterial genomes has expanded, enabling structural studies on known gene-coded proteins to accelerate. This review focuses on the advances in mass spectrometry (MS) that have enabled structural proteomics studies to be performed on the proteins and protein complexes within cyanobacteria. The review also...
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Essays Biochem (2023) 67 (2): 243–253.
Published: 29 March 2023
... and their aggregation mechanisms continues to receive increased attention. Mass spectrometry (MS) has firmly established itself as a powerful analytical tool capable of both detection and characterization of proteins at all levels of structure. Given inherent advantages of biological MS, including high sensitivity...
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Essays Biochem (2023) 67 (2): 165–174.
Published: 29 March 2023
... mass spectrometry (HDX-MS), this exchange process is used to extract information about biomolecular structure and dynamics. This minireview focuses on millisecond timescale HDX-MS measurements, which, while less common than ‘conventional’ timescale (seconds to hours) HDX-MS, provide a unique window...
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Essays Biochem (2023) 67 (2): 175–186.
Published: 29 March 2023
... complexes and mutually affect their functions. In the present mini-review, we will first provide an overview of different mass spectrometry (MS)-based methods to study the RNA-binding proteome (RBPome), most of which are based on photochemical cross-linking. As we will show, some of these methods are also...
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Essays Biochem (2023) 67 (2): 147–149.
Published: 29 March 2023
...Hannah M. Britt; Rebecca Beveridge; Antonio N. Calabrese Mass spectrometry (MS) is now established as an analytical tool to interrogate the structure and dynamics of proteins and their assemblies. An array of MS-based technologies has been developed, with each providing unique information...
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Essays Biochem (2020) 64 (1): 135–153.
Published: 20 January 2020
...Lauren Elizabeth Smith; Adelina Rogowska-Wrzesinska Post-translational modifications (PTMs) are integral to the regulation of protein function, characterising their role in this process is vital to understanding how cells work in both healthy and diseased states. Mass spectrometry (MS) facilitates...