...Jessica E. Fellmeth; Kim S. McKim While many of the proteins involved in the mitotic centromere and kinetochore are conserved in meiosis, they often gain a novel function due to the unique needs of homolog segregation during meiosis I (MI). CENP-C is a critical component of the centromere...

...Binyam Mogessie Eggs are produced from progenitor oocytes through meiotic cell division. Fidelity of meiosis is critical for healthy embryogenesis – fertilisation of aneuploid eggs that contain the wrong number of chromosomes is a leading cause of genetic disorders including Down’s syndrome, human...

...Gisela Cairo; Soni Lacefield Faithful chromosome segregation in mitosis and meiosis requires that chromosomes properly attach to spindle microtubules. Initial kinetochore-microtubule attachments are often incorrect and rely on error correction mechanisms to release improper attachments, allowing...

...Reinier F. Prosée; Joanna M. Wenda; Florian A. Steiner The aim of mitosis is to segregate duplicated chromosomes equally into daughter cells during cell division. Meiosis serves a similar purpose, but additionally separates homologous chromosomes to produce haploid gametes for sexual reproduction...