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Keywords: metabolic engineering
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Articles
Essays Biochem (2021) 65 (2): 197–212.
Published: 26 July 2021
... and a range of bulk chemicals at high titre and yield. The product portfolio of the microbe is continuously expanding. Moreover, metabolically engineered strains of C. glutamicum produce more than 30 high value active ingredients, including signature molecules of raspberry, savoury, and orange...
Articles
Essays Biochem (2021) 65 (2): 381–392.
Published: 26 July 2021
..., provide an overview of the available genetic engineering tools and recent advances in metabolic engineering of V. natriegens . Finally, we discuss the obstacles which have to be overcome in order to establish V. natriegens as industrial production host. Correspondence: Bastian Blombach...
Articles
Essays Biochem (2021) 65 (2): 277–291.
Published: 26 July 2021
... product ( Figure 2 ). The basic metabolic engineering strategies include up-regulation of the activity and expression of the most limiting biosynthetic enzymes, as well as deletion of enzymes competing for or degrading precursor metabolites. Such modifications can be readily carried out in S. cerevisiae...
Articles
Essays Biochem (2021) 65 (2): 309–318.
Published: 26 July 2021
... large pool of information generated in the fundamental studies has facilitated the development of a broad range of sophisticated and robust tools for the genome and metabolic engineering of ADP1. This mini-review outlines and describes the recent advances in ADP1 engineering and tool development...
Articles
Essays Biochem (2021) 65 (2): 293–307.
Published: 26 July 2021
... highlighted as well. Correspondence: Brigitte Gasser ( brigitte.gasser@boku.ac.at ) 03 02 2021 09 03 2021 29 03 2021 © 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 metabolic engineering recombinant proteins synthetic...
Articles
Essays Biochem (2021) 65 (2): 393–403.
Published: 26 July 2021
... traditional chassis, typically, Escherichia coli, Bacillus subtilis, Pseudomonas putida and Corynebacterium glutamicum . The advantages and current status of Halomonas spp. including their molecular biology and metabolic engineering approaches as well as their applications are reviewed here. Moreover, a...
Includes: Supplementary data
Articles
Essays Biochem (2021) 65 (2): 173–185.
Published: 26 July 2021
... proteins production are summarized. Further, the recent progress in employing metabolic engineering and synthetic biology strategies in B. subtilis platform strain to produce commodity chemicals is systematically introduced and compared. Finally, the major limitations for the further development of B...
Articles
Essays Biochem (2021) 65 (2): 225–246.
Published: 26 July 2021
... including climate change. Also, bio-based production, instead of chemical synthesis, of food ingredients and natural products has gained ever increasing interest for health benefits. Systems metabolic engineering allows more efficient development of microbial cell factories capable of sustainable, green...
Articles
Essays Biochem (2021) 65 (2): 261–275.
Published: 26 July 2021
... sustainable biobased production of complex molecules, there is a great renewed interest in exploring and engineering the biosynthetic potential of streptomycetes. Here, we describe the Design-Build-Test-Learn (DBTL) cycle for metabolic engineering experiments in streptomycetes and how it can be used for the...
Articles
Essays Biochem (2019) 63 (2): 267–284.
Published: 26 June 2019
... of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Genome Engineering in-silico Metabolic Engineering metabolic models whole-cell models Synthetic biology is the rational design and engineering of cells and cellular systems using...
Articles
Essays Biochem (2018) 62 (1): 41–50.
Published: 27 February 2018
... metabolic engineering techniques using synthetic biology have set the stage for production yields to become economically attractive, but more refined design strategies are required to increase product yields without compromising development and growth of the host system. The ability of plant cells to...
Articles
Essays Biochem (2016) 60 (4): 303–313.
Published: 30 November 2016
..., transcriptional and translational machinery). We highlight Pseudomonas putida , widely used in many different biotechnological applications as a prominent organism for synthetic biology due to its metabolic diversity, robustness and ease of manipulation. metabolic engineering microbiology modularity...