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Keywords: metabolism
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Essays Biochem (2024) EBC20230079.
Published: 12 June 2024
...Joseph J. Provost; Kathleen A Cornely; Pamela S. Mertz; Celeste N. Peterson; Sophie G. Riley; Harrison J. Tarbox; Shree R. Narasimhan; Andrew J Pulido; Amy L. Springer Malate dehydrogenase (MDH) is a key enzyme in mammalian metabolic pathways in cytosolic and mitochondrial compartments. Regulation...
Articles
Essays Biochem (2023) 67 (5): 853–863.
Published: 13 September 2023
... function connects the methionine and folate cycles, making it a crucial node in primary metabolism, with impacts on important cellular processes such as anabolism, growth and synthesis of proteins, polyamines, nucleotides and lipids. As a result, MetHs are vital for the viability or virulence of numerous...
Articles
Essays Biochem (2023) 67 (4): 753–768.
Published: 11 August 2023
... to these environments. Here, we review the literature and identify knowledge gaps on the metabolic diversity, ecological distribution, and physiological adaptations of nitrifying microorganisms in acidic and alkaline environments. We emphasise that nitrifying microorganisms depend on a suite of physiological...
Articles
Essays Biochem (2023) 67 (4): 653–670.
Published: 11 August 2023
... disequilibria, commonly existing as redox disequilibria. Metals are significant players in controlling redox reactions, as they are essential components of the engine that life uses to tap into the thermodynamic disequilibria necessary for metabolism. The number of proteins that evolved to catalyze redox...
Includes: Supplementary data
Articles
Essays Biochem (2023) 67 (1): 63–75.
Published: 03 March 2023
... of mitochondria, with functional microdomains exhibiting widespread activities, such as controlling local metabolism and Ca 2+ signaling. Ca 2+ is an ion of utmost importance, both physiologically and pathologically, and participates in critical central nervous system processes, including synaptic plasticity...
Articles
Essays Biochem (2023) 67 (1): 1–2.
Published: 03 March 2023
... according to different organismal conditions. By acting as sentinel cells, astrocytes thus co-ordinate gene expression profiles, immune responses, signal transduction pathways, and metabolic programs that play essential roles in the formation of brain circuits to modulate neurotransmission and higher-order...
Articles
Essays Biochem (2022) 66 (1): 53–63.
Published: 29 April 2022
... biochemistry classroom during the teaching of metabolism. We present student comments on the activity and the models that were generated by the students. Additionally, we focus on other instructor and project student-designed models for the teaching of ATP synthesis, gene regulation and restriction digestion...
Includes: Supplementary data
Articles
Essays Biochem (2020) 64 (4): 607–647.
Published: 24 August 2020
...Ayesha Judge; Michael S. Dodd Metabolism consists of a series of reactions that occur within cells of living organisms to sustain life. The process of metabolism involves many interconnected cellular pathways to ultimately provide cells with the energy required to carry out their function...
Articles
Essays Biochem (2020) 64 (3): 397–399.
Published: 10 July 2020
... receptors to stimulate the cells of origin (autocrine) or nearby cells (paracrine). Lipid mediators are involved in many physiological processes, which may become dysregulated during ageing and in lipid-related diseases such as diabetes, atherosclerosis, arthritis, cancer, Alzheimer’s disease and metabolic...
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Essays Biochem (2018) 62 (2): 165–175.
Published: 01 May 2018
... with and modulate the function of their target cells. The regulation of whole-body metabolism requires cross-talk between key metabolic tissues including adipose tissue (AT), the liver and skeletal muscle. Furthermore, the regulation of nutrient/energy allocation during pregnancy requires co-ordinated communication...
Articles
Essays Biochem (2017) 61 (3): 349–368.
Published: 11 July 2017
... the lifespan of an organism but also refers to progressive functional impairment and disease. The nutrient-sensing kinase mTOR (mammalian target of rapamycin) is a major determinant of ageing. mTOR promotes cell growth and controls central metabolic pathways including protein biosynthesis, autophagy...
Articles
Essays Biochem (2016) 60 (5): 407.
Published: 15 December 2016
...Philip Newsholme; Philip Newsholme Correspondence: Philip Newsholme ( philip.newsholme@curtin.edu.au ) © 2016 The Author(s). published by Portland Press Limited on behalf of the Biochemical Society 2016 lipids metabolism nutrition The application of metabolomics...
Articles
Essays Biochem (2016) 60 (5): 409–418.
Published: 15 December 2016
...Philip Newsholme; Jarlei Fiamoncini; Rui Curi; Hannelore Daniel The modulation of energy expenditure by dietary administration of cholic acid in mice promoted interest in studying bile acid(s) (BA) as adjuvants in the treatment of metabolic diseases such as obesity and diabetes. Bile acids can...