... molecular dynamics (MD), hybrid quantum mechanics/molecular mechanics (QM/MM), and enhanced sampling techniques) are described for nonexpert readers. Finally, we provide three examples of the application of these methods to unravel the catalytic mechanisms of three disease-related CAZymes: β...

... & Publish pilot with Portland Press and the Biochemical Society under a transformative agreement with JISC. allosteric regulation intrinsically disordered proteins molecular mechanisms phosphorylation/dephosphorylation post translational modification protein-protein interactions Protein...

... of health and disease molecular mechanisms Basement membranes (BMs) are specialised extracellular matrix (ECM) structures that compartmentalise tissues, provide structural support and influence cell behaviour and signalling. BMs underlie epithelial and endothelial cells, surround smooth muscle, fat...

...-translational modifications modulating these processes. Understanding the molecular mechanisms controlling mitochondrial dynamics is crucial to decipher how mitochondrial shape meets the function and to increase the knowledge on the molecular basis of diseases associated with morphology defects. This article...

... methylation at A2503 within the 23S rRNA of ribosomal large subunit, thereby disrupting an interaction between drug and target. antibiotics Clostridium difficile drug resistance molecular mechanisms Clostridium difficile is the leading cause of nosocomial diarrhoea ranging from mild to life...