... neurodegeneration neurons Astrocytes are morphologically and functionally flexible cells that readily have capacity to adapt to external conditions. To achieve this, astrocytes are required to translate and communicate specific signals for the rest of the brain. Understanding the specific molecular mechanisms...

... ABC transport proteins Alzheimers disease lipids neurodegeneration ATP-binding cassette (ABC) transporters are amongst the largest protein superfamily groups with 48 proteins classified into seven subfamilies, ABCA, ABCB, ABCC, ABCD, ABCE, ABCF and ABCG. ABC transporters are generally...

... MLRs can mitigate AD-associated neurodegeneration [ 45 ]. For the purposes of this review, two classes of lipid-modifying enzymes important for MLR homeostasis will be discussed: phospholipases (PLs) and sphingomyelinases (SMases). We aim to summarise evidence linking the function of PLs and SMases...

... of University of Cambridge in an all-inclusive Read & Publish pilot with Portland Press and the Biochemical Society under a transformative agreement with JISC. cell death neurodegeneration tau In 2022, it will be 50 years since the article by Kerr et al. [ 1 ] appeared that coined...

...Patrick A. Lewis Cellular control of vesicle biology and trafficking is critical for cell viability, with disruption of these pathways within the cells of the central nervous system resulting in neurodegeneration and disease. The past two decades have provided important insights into both...

... dementia Genome instability Neurodegeneration Repeat expansion Amyotrophic lateral sclerosis (ALS) is a lethal degenerative motor neuron disease with a median survival of 2–4 years after diagnosis [ 1 ] and no available effective treatment [ 2 ]. Caused by loss of motor neurons in the motor cortex...

... estimates predict the cost could reach 17% of the NHS budget. cardiovascular disease cancer metabolic disorders molecular basis of health and disease microbiology neurodegeneration © 2018 The Author(s). 2018 This is an open access article published by Portland Press Limited on behalf...

... A. Brellinger C. Schweizer M. Nitsch R.M. Reifegerste R. Age-dependent neurodegeneration and Alzheimer-amyloid plaque formation in transgenic Drosophila J. Neurosci. 2004 24 3899 3906 6. Iijima K. Liu H.P. Chiang A.S. Hearn S.A. Konsolaki M. Zhong Y...

... ]. Alzheimer's disease hyperphosphorylation neurodegeneration tau tauopathies Nitration is the addition of nitrogen dioxide on a tyrosine residue of an organic molecule. Four nitration sites have been identified in tau proteins, i.e. Tyr 18 , Tyr 29 , Tyr 197 and Tyr 394 . Nitration of Tyr 29 seems...

... in our ‘ageing’ world. 1 To whom correspondence should be addressed (email [email protected] ). © The Authors Journal compilation © 2013 Biochemical Society 2013 AMPK inflammation mTOR neurodegeneration protein aggregation ROS cellular senescence Autophagy...