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1-13 of 13
Keywords: protein aggregation
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Articles
Journal:
Essays in Biochemistry
Essays Biochem (2023) 67 (2): 243–253.
Published: 29 March 2023
...Tara L. Pukala Protein aggregation is now recognized as a generic and significant component of the protein energy landscape. Occurring through a complex and dynamic pathway of structural interconversion, the assembly of misfolded proteins to form soluble oligomers and insoluble aggregates remains...
Articles
Journal:
Essays in Biochemistry
Essays Biochem (2022) 66 (7): 977–986.
Published: 16 December 2022
... Attribution License 4.0 (CC BY-NC-ND) . alpha synuclein amyloid copper metal binding Parkinsons disease protein aggregation Parkinson’s disease (PD), for which there is only symptomatic treatment [ 1 , 2 ], is the second most common neurodegenerative disorder after Alzheimer’s disease...
Articles
Journal:
Essays in Biochemistry
Essays Biochem (2022) 66 (7): 959–975.
Published: 16 December 2022
... 08 08 2022 © 2022 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2022 accelerator amyloid energy landscape inhibitor protein aggregation small-molecule modulator Amyloidosis is a class of protein-misfolding diseases characterised...
Articles
Journal:
Essays in Biochemistry
Essays Biochem (2022) 66 (7): 987–1000.
Published: 16 December 2022
... into protein aggregates, which have been widely implicated in Parkinson’s disease (PD) pathogenesis and other synucleinopathies. The self-assembly of α-Syn involves the structural conversion of soluble monomeric protein into oligomeric intermediates and eventually fibrillar aggregates of amyloids with cross-β...
Articles
Journal:
Essays in Biochemistry
Essays Biochem (2022) 66 (7): 891–900.
Published: 16 December 2022
[email protected] ) 20 09 2022 13 11 2022 14 11 2022 © 2022 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2022 fluorescence resonance energy transfer phase separation protein aggregation protein conformation protein dynamics single molecule...
Articles
Journal:
Essays in Biochemistry
Essays Biochem (2016) 60 (2): 173–180.
Published: 15 October 2016
... of the Biochemical Society and distributed under the Creative Commons Attribution Licence 4.0 (CC BY) . amyloid autophagy chaperone-mediated autophagy immunoglobulin light chain lysosome macroautophagy mTOR Parkinson's disease protein aggregation protein misfolding proteostasis rapamycin TFEB α...
Articles
Journal:
Essays in Biochemistry
Essays Biochem (2016) 60 (2): 143–151.
Published: 15 October 2016
... phenotypes and are closely linked with the accumulation of microscopically visible deposits of aggregated proteins. These include inclusion bodies found in AD (Alzheimer's disease), HD (Huntington's disease) and ALS (amyotrophic lateral sclerosis) patient neurons. Protein aggregation is intimately linked...
Articles
Journal:
Essays in Biochemistry
Essays Biochem (2016) 60 (2): 163–172.
Published: 15 October 2016
... 2016 © 2016 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2016 α-crystallin Hsp27 molecular chaperones protein aggregation protein folding regulation of apoptosis regulation of sHsps structure of sHsps substrate binding We apologize...
Articles
Journal:
Essays in Biochemistry
Essays Biochem (2016) 60 (2): 181–190.
Published: 15 October 2016
... in affected cells and tissues. In this article, we recap amyloid aggregation pathways, describe prion-like propagation, elaborate on detrimental interactions of protein aggregates with the cellular protein quality control system and discuss why some aggregates are toxic, whereas others seem to be beneficial...
Articles
Journal:
Essays in Biochemistry
Essays Biochem (2014) 56: 167–180.
Published: 18 August 2014
... (−)-epigallocatechin gallate (EGCG) Huntington's disease inclusion body nucleation-dependent polymerization polyglutamine disease protein aggregation PolyQ (polyglutamine) tracts with lengths of between five and 30 glutamine residues are conserved and found in 0.34% of all human proteins, indicating...
Articles
Journal:
Essays in Biochemistry
Essays Biochem (2014) 56: 149–165.
Published: 18 August 2014
.... 1 To whom correspondence should be addressed (email [email protected] ). © The Authors Journal compilation © 2014 Biochemical Society 2014 amyotrophic lateral sclerosis (ALS) Cu,Zn superoxide dismutase (SOD1) misfolding protein aggregation protein stability ALS...
Articles
Journal:
Essays in Biochemistry
Essays Biochem (2014) 56: 53–68.
Published: 18 August 2014
...-shock protein Hsc70 (heat-shock cognate 70) Hsp90 (heat-shock protein 90) protein aggregation protein folding proteostasis The native state of functional proteins is a delicate, flexible and, in many cases, metastable conformation. Spontaneous folding to this native state was demonstrated...
Articles
Journal:
Essays in Biochemistry
Essays Biochem (2013) 55: 119–131.
Published: 27 September 2013
... are associated with increased cellular stress and assault including DNA damage, reduced energy availability, protein aggregation and accumulation of damaged organelles. A reduction in autophagy activity has been observed in a number of ageing models and its up-regulation via pharmacological and genetic methods...