...Joseph J. Provost; Amy D. Parente; Kristin M. Slade; Thomas J. Wiese In this review, we examine the protein–protein interactions of cytosolic malate dehydrogenase (MDH), an under-studied area in cellular metabolism. We provide a comprehensive overview of MDH involvement in metabolism, especially...

... filamentous fungi GFP Trap Immunoprecpitation protein complexes protein-protein interactions Tandem Affinity Purification The kingdom Fungi comprises a highly diverse group of eukaryotes, estimated to include approximately 5 million species [ 1 ]. Among them, filamentous fungi are particularly...

... access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Cyanobacteria mass spectrometry post translational modification protein-protein interactions proteomics Cyanobacteria...

... The Author(s). 2023 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Crosslinking in situ protein-protein interactions proteomics The study of protein...

... separation Membraneless organelle Protein-protein interactions Soft matter Water structure From the viewpoint of physics, most biological materials (ranging from biological macromolecules and membranes to cellular organelles, cells, and tissues), with their characteristic possibility to have...

.... allosteric regulation intrinsically disordered proteins molecular mechanisms phosphorylation/dephosphorylation post translational modification protein-protein interactions Protein phosphorylation is a common and reversible post-translational modification (PTM) that results in the addition...

... and structural disorder in protein-protein interactions . Trends Biochem. Sci. 33 , 2 – 8 18054235 10.1016/j.tibs.2007.10.003 14. Fuxreiter M. ( 2018 ) Fuzziness in protein interactions-a historical perspective . J. Mol. Biol. 430 , 2278 – 2287 29477337 10.1016/j.jmb.2018.02.015...

... of these protein–protein interactions are mediated through the recognition of host globular domains by short linear motifs (SLiMs), or longer intrinsically disordered domains (IDD), in the disordered regions of viral proteins. However, viruses also employ their own globular domains for binding to SLiMs and IDDs...

... Conformational dynamics Nanopores protein dynamics protein-protein interactions Single-molecule kinetics Proteins are the workhorses in our body [ 1 ]. They convert energy into function, and form complex dynamic protein–protein interaction networks. Protein function relies crucially on structured...

... (TOGL1) is located at their N-terminus. The shorter isoforms (CLASP2-β and -γ) do not have TOGL1. All isoforms contain two other TOGL domains (TOGL2 and -3), which surround the SxIP motif-containing S/R region, and a C-terminal protein–protein interaction domain, which binds factors such as the +TIPs...

... glycolysis protein-protein interactions Catalytic domains do not operate in isolation, but instead frequently form molecular machines or protein complexes that integrate enzymatic activities ( Figure 1 ). Sometimes, several catalytic sites – that catalyze subsequent steps in a metabolic process...

... with a recently published case study of a drug discovery programme targeting the challenging protein–protein interaction Kelch-like ECH-associated protein 1:nuclear factor erythroid 2-related factor 2. Correspondence: Benjamin D. Cons ( [email protected] ) 11 07 2017 26 09 2017 27 09 2017...

..., underscore the importance of protein–protein interactions and intramolecular contacts to the mode of action of this class of compounds. These discoveries have opened the door to a new paradigm for structure-guided drug design: borrowing surface area and molecular recognition from nature to elicit cellular...