... and applications of this information to accelerate modern agriculture breeding programmes and optimize energy use efficiency in proteostasis. Correspondence: A. Harvey Millar ( [email protected] ) 09 02 2022 07 06 2022 27 06 2022 © 2022 The Author(s). 2022 This is an open...

... in recent years, through the development and application of powerful technologies including genome sequencing, a pantheon of ‘omics techniques, precise genome editing, and step changes in structural biology and microscopy. Proteostasis – the collective processes that control the protein complement...

...Ernesto Llamas; Pablo Pulido Several protein homeostasis (proteostasis) pathways safeguard the integrity of thousands of proteins that localize in plant chloroplasts, the indispensable organelles that perform photosynthesis, produce metabolites, and sense environmental stimuli. In this review, we...

...Michael J. Skelly Proper regulation of protein homeostasis (proteostasis) is essential for all organisms to survive. A diverse range of post-translational modifications (PTMs) allow precise control of protein abundance, function and cellular localisation. In eukaryotic cells, ubiquitination...

... regions called LC3-interacting region (LIR) motifs [ 48 , 49 ]. A prime example of this is the well-known receptor protein, p62/SQSTM1, which links cargo to ATG8, for example during cytosolic protein aggregate autophagy. The UPR acts to restore defective proteostasis upon detection of unfolded protein...

...Patricija van Oosten-Hawle; Matthew P. Jackson; Eric W. Hewitt Proteostasis refers to the regulation of the cellular concentration, folding, interactions and localization of each of the proteins that comprise the proteome. One essential element of proteostasis is the disposal of misfolded proteins...

... amyloid autophagy chaperones degradation deposition disaggregase misfolding polyQ proteasome protein quality control proteostasis In order to fulfil their physiological functions, proteins need to fold into their unique three-dimensional structure. Even correctly folded proteins...

... discuss emerging insights and provide specific examples on how components of the cell-non-autonomous proteostasis network are used in cancer and protein-folding diseases to drive disease progression across tissues. * Correspondence: Patricija van Oosten-Hawle (email [email protected]...

...Patricija van Oosten-Hawle; John S. Bett Cells have developed an evolutionary obligation to survey and maintain proteome fidelity and avoid the possible toxic consequences of protein misfolding and aggregation. Disturbances to protein homoeostasis (proteostasis) can result in severe cellular...

... disaggregation protein homoeostasis protein-misfolding disorders proteostasis proteotoxicity Multiple proteins have the intrinsic ability to misfold and convert from a soluble into an alternative conformation, which can form amyloids, infamous protein aggregates, associated with a specific subgroup...

... H3K9/K27 histone modifications in the sperm [ 25 ]. Although transgenerational proteostasis-related phenotypes were not reported, maternal exposure to high dietary glucose in C. elegans is known to be protective against cellular stress and also reduces age-dependent proteotoxicity in the next...

... 2016 C. elegans chaperone folding heat shock proteins (Hsp) Hsp100 Hsp60 Hsp70 Hsp90 proteostasis sHsp The term ‘molecular chaperones’ was subsequently adopted by John Ellis [ 5 ], who relied on sequence comparisons to suggest that bacterial GroEL and chloroplast Hsp60 could...

... of these diseases and provide potential targets for therapy. It is necessary that cells continuously safeguard the functionality of their proteins and the general protein homoeostasis, termed proteostasis [ 8 , 9 ]. This is challenging even during normal growth periods, but in particular after exposure...