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Keywords: systems biology
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Articles
Essays Biochem (2021) 65 (2): 293–307.
Published: 26 July 2021
... biology systems biology yeast Methylotrophic yeasts raised the interest of biotechnologists first for their ability to grow on methanol as the only carbon and energy source, thus promising the production of cheap protein-rich biomass for animal and human nutrition [ 1 ]. The oil crisis in the...
Articles
Essays Biochem (2018) 62 (4): 483–486.
Published: 26 October 2018
...Walter Kolch; Dirk Fey; Colm J. Ryan In this issue of Essays in Biochemistry , biochemistry meets systems biology—a blind date that may hold all the promises, pitfalls and failures of a relationship where a new discipline has been sprung upon a well-established one. As the articles in this issue...
Articles
Essays Biochem (2018) 62 (4): 549–561.
Published: 26 October 2018
... Society 2018 Systems Biology Integrative workflows Network analysis Disease signatures Therapeutic targets Technological advances generate a remarkable variety of data to characterize the components of molecular and cellular systems. When we started our work in cancer systems biology 20...
Articles
Essays Biochem (2018) 62 (4): 487–500.
Published: 04 October 2018
...Iman Tavassoly; Joseph Goldfarb; Ravi Iyengar Systems biology is an integrative discipline connecting the molecular components within a single biological scale and also among different scales (e.g. cells, tissues and organ systems) to physiological functions and organismal phenotypes through...
Articles
Essays Biochem (2018) 62 (4): 607–617.
Published: 23 August 2018
... have the necessary sensitivity, selectivity, and spatial resolution to usefully probe heterocellular signaling processes, but these are best used to test specific, mechanistic models. Decades of systems biology research with monocultures has provided a solid foundation for building models of...
Articles
Essays Biochem (2018) 62 (4): 515–524.
Published: 23 August 2018
... transduction studies. On a university campus, individuals skilled in these areas can be found in a wide range of departments, including the usual suspects of systems biology, statistics, physics, and various engineering fields. However, there are now many similarly trained researchers in less obvious...
Articles
Essays Biochem (2018) 62 (4): 525–534.
Published: 02 August 2018
... 4.0 (CC BY) . biological networks intracellular signaling phosphorylation/dephosphorylation systems biology Cells transduce and integrate environmental stimuli through a variety of intracellular signalling mechanisms in order to generate appropriate and timely physiological...
Articles
Essays Biochem (2017) 61 (3): 379–388.
Published: 11 July 2017
... profiling has the potential to help identify the underlying causal mechanisms that link genotype to phenotype. We present a brief review of proteomics and metabolomics in ageing research with a focus on the potential of a systems biology and network-centric perspective in geroscience. While network analyses...
Articles
Essays Biochem (2017) 61 (3): 369–377.
Published: 11 July 2017
... void of limitations, both methods contribute useful information to the parameter estimation process and can be used in conjunction with each other [ 13 ]. Model calibration in systems biology is particularly difficult due to a lack of detailed knowledge concerning the topological structure of a...