... peroxiredoxins systems biology thiols thioredoxin National Research Foundation (NRF) 501100001321 138096 Cysteine biosynthesis is believed to have evolved after the so-called abiotic and chaotropic amino acids [ 1 ] and conferred several remarkable properties to living systems...

... Press Limited on behalf of the Biochemical Society 2021 metabolic engineering recombinant proteins synthetic biology systems biology yeast Methylotrophic yeasts raised the interest of biotechnologists first for their ability to grow on methanol as the only carbon and energy source...

...Walter Kolch; Dirk Fey; Colm J. Ryan In this issue of Essays in Biochemistry , biochemistry meets systems biology—a blind date that may hold all the promises, pitfalls and failures of a relationship where a new discipline has been sprung upon a well-established one. As the articles in this issue...

... Society 2018 Systems Biology Integrative workflows Network analysis Disease signatures Therapeutic targets Technological advances generate a remarkable variety of data to characterize the components of molecular and cellular systems. When we started our work in cancer systems biology 20...

...Iman Tavassoly; Joseph Goldfarb; Ravi Iyengar Systems biology is an integrative discipline connecting the molecular components within a single biological scale and also among different scales (e.g. cells, tissues and organ systems) to physiological functions and organismal phenotypes through...

... the necessary sensitivity, selectivity, and spatial resolution to usefully probe heterocellular signaling processes, but these are best used to test specific, mechanistic models. Decades of systems biology research with monocultures has provided a solid foundation for building models of heterocellular signaling...

... campus, individuals skilled in these areas can be found in a wide range of departments, including the usual suspects of systems biology, statistics, physics, and various engineering fields. However, there are now many similarly trained researchers in less obvious disciplines, including plant biology...

... BY) . biological networks intracellular signaling phosphorylation/dephosphorylation systems biology Cells transduce and integrate environmental stimuli through a variety of intracellular signalling mechanisms in order to generate appropriate and timely physiological responses. The reversible...

... profiling has the potential to help identify the underlying causal mechanisms that link genotype to phenotype. We present a brief review of proteomics and metabolomics in ageing research with a focus on the potential of a systems biology and network-centric perspective in geroscience. While network analyses...

... License 4.0 (CC BY) . aging cell homeostasis systems biology The process of ageing is multi-factorial and complex. Despite the complexity simple interventions such as inhibition of mTOR, activation of autophagy and supplementation with NAD are known to modulate the process of ageing...