... is regulated by the transcription factor LEU3 in S. cerevisiae , and LeuB in Aspergillus nidulans and Aspergillus fumigatus , and the activity of these transcription factors is modulated by the leucine biosynthesis pathway intermediate α-isopropylmalate. Herein, we discuss recent advances in our understanding...

...Éléa Héberlé; Anaïs Flore Bardet Dynamic binding of transcription factors (TFs) to regulatory elements controls transcriptional states throughout organism development. Epigenetics modifications, such as DNA methylation mostly within cytosine-guanine dinucleotides (CpGs), have the potential...

... transcription factor For many decades, it has generally been accepted that in order to function, proteins must adopt a defined 3D structure (this has become known as the structure–function paradigm). However, it has increasingly become apparent that a large percentage of the proteome consists...