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Keywords: tumorigenesis
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Essays Biochem (2013) 55: 133–151.
Published: 27 September 2013
... ]. Below, we briefly discuss how some of these signalling pathways, such as the RAS–RAF–MEK1/2 [MAPK (mitogen-activated protein kinase)/ERK (extracellular-signal-regulated kinase) kinase 1/2]–ERK1/2, PI3K–Akt–mTORC1 and p53, which are frequently deregulated in cancer and are important for tumorigenesis...