... the ER lumen. Signalling sensors within the ER detect perturbations within the lumen (ER stress) and employ downstream signalling cascades that engage effector mechanisms to restore homeostasis. The most studied signalling mechanism that the ER employs is the unfolded protein response (UPR), which...

...-shock response protein-misfolding diseases proteostasis stress responses systemic proteostasis transcellular chaperone signalling unfolded protein response In this section, we address how the classical compartment-specific stress responses that traditionally have been known to function...