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In vitro and in vivo models are essential to our understanding of human disease. But how well can a rodent model really capture a human disease? This has been a major challenge for complex disorders that involve the nervous system. Recent advances in stem cell technology have enabled the culture of human, patient-specific, neurons and also tissue-based brain models termed “organoids”. But to what extent can these fully capture the complexity of the human brain and so provide insight into the causes and treatment of neuronal disorders?
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Emerging technologies for research models of human neuronal disorders in vivo and in vitro
Open for submissions
In vitro and in vivo models are essential to our understanding of human disease. But how well can a rodent model really capture a human disease? This has been a major challenge for complex disorders that involve the nervous system. Recent advances in stem cell technology have enabled the culture of human, patient-specific, neurons and also tissue-based brain models termed “organoids”. But to what extent can these fully capture the complexity of the human brain and so provide insight into the causes and treatment of neuronal disorders?This themed collection in Neuronal Signaling aims to share advances in disease modelling and explore how both in vivo and in vitro models can enhance our understanding of neuronal disorders, as well as their prevention and treatment. The collection will be edited by Professor Clare Stanford and Dr Tom Cunningham and is based on the symposium, ‘From stem cells to whole animals: the scope and appraisal of research models in vitro and in vivo’, at the BNA Festival of Neuroscience (2021). We invite submission of original research articles, reviews and perspective pieces on this topic for publication in this themed collection.
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Emerging technologies for research models of human neuronal disorders
in
vivo and in vitro
