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Articles

Modelling Alzheimer’s disease in a dish: dissecting amyloid-β metabolism in human neurons

Open Access
Elizabeth Hill, Thomas J. Cunningham
Journal: Neuronal Signaling
Neuronal Signal (2024) 8 (1): NS20230020.
https://doi.org/10.1042/NS20230020
Published: 11 January 2024
View article titled, Modelling Alzheimer’s disease in a dish: dissecting amyloid-β metabolism in human neurons
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Articles

Cytokine activity in Parkinson’s disease

Open Access
Nicolas Dzamko
Journal: Neuronal Signaling
Neuronal Signal (2023) 7 (4): NS20220063.
https://doi.org/10.1042/NS20220063
Published: 04 December 2023
View article titled, Cytokine activity in Parkinson’s disease
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Articles

Inflammation and emotion regulation: a narrative review of evidence and mechanisms in emotion dysregulation disorders

Open Access
Flavia Petruso, Alexis E. Giff, Beatrice A. Milano, Maurilio Menduni De Rossi, Luigi Francesco Saccaro
Journal: Neuronal Signaling
Neuronal Signal (2023) 7 (4): NS20220077.
https://doi.org/10.1042/NS20220077
Published: 15 November 2023
View article titled, Inflammation and emotion regulation: a narrative review of evidence and mechanisms in emotion dysregulation disorders
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Articles

Inhibition of insulin-degrading enzyme in human neurons promotes amyloid-β deposition

Open Access
Helen A. Rowland, Samuel R. Moxon, Nicola J. Corbett, Kelsey Hanson, Kate Fisher, Katherine A.B. Kellett, Nigel M. Hooper
Journal: Neuronal Signaling
Neuronal Signal (2023) 7 (4): NS20230016.
https://doi.org/10.1042/NS20230016
Published: 03 October 2023
View article titled, Inhibition of insulin-degrading enzyme in human neurons promotes amyloid-β deposition
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Articles

Modeling Parkinson’s disease in LRRK2 rodents

Open Access
Chiara Domenicale, Stefano Magnabosco, Michele Morari
Journal: Neuronal Signaling
Neuronal Signal (2023) 7 (3): NS20220040.
https://doi.org/10.1042/NS20220040
Published: 16 August 2023
View article titled, Modeling Parkinson’s disease in LRRK2 rodents
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Articles

Endocannabinoid signaling and epigenetics modifications in the neurobiology of stress-related disorders

Open Access
Arthur A. Coelho, Sávio Lima-Bastos, Pedro H. Gobira, Sabrina F. Lisboa
Journal: Neuronal Signaling
Neuronal Signal (2023) 7 (2): NS20220034.
https://doi.org/10.1042/NS20220034
Published: 25 July 2023
View article titled, Endocannabinoid signaling and epigenetics modifications in the neurobiology of stress-related disorders
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Articles

Inflammation in the pathogenesis of depression: a disorder of neuroimmune origin

Open Access
Myles Corrigan, Aoife M. O'Rourke, Barry Moran, Jean M. Fletcher, Andrew Harkin
Journal: Neuronal Signaling
Neuronal Signal (2023) 7 (2): NS20220054.
https://doi.org/10.1042/NS20220054
Published: 13 July 2023
View article titled, Inflammation in the pathogenesis of depression: a disorder of neuroimmune origin
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Articles

Maternal immune activation and role of placenta in the prenatal programming of neurodevelopmental disorders

Open Access
Rebecca M. Woods, Jarred M. Lorusso, Jennifer Fletcher, Heidi ElTaher, Francesca McEwan, Isabella Harris, Hager M. Kowash, Stephen W. D'Souza, Michael Harte, Reinmar Hager, Jocelyn D. Glazier
Journal: Neuronal Signaling
Neuronal Signal (2023) 7 (2): NS20220064.
https://doi.org/10.1042/NS20220064
Published: 31 May 2023
View article titled, Maternal immune activation and role of placenta in the prenatal programming of neurodevelopmental disorders
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Articles

Paternal early life stress exerts intergenerational effects on male C57Bl/6J offspring risk-taking behaviors and predator scent-induced c-Fos expression

Open Access
Ulysse M.C.C. Thivisol, Phoebe Ho, Baijia Li, Mari Trompke, Lucas B. Hoffmann, Anthony J. Hannan, Terence Y. Pang
Journal: Neuronal Signaling
Neuronal Signal (2023) 7 (2): NS20220097.
https://doi.org/10.1042/NS20220097
Published: 28 April 2023
View article titled, Paternal early life stress exerts intergenerational effects on male C57Bl/6J offspring risk-taking behaviors and predator scent-induced c-Fos expression
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Includes: Supplementary data
Articles

In vivo imaging of axonal transport in peripheral nerves of rodent forelimbs

Open Access
In Collection
Emerging technologies for research models of human neuronal disorders in vivo and in vitro
Qiuhan Lang, Giampietro Schiavo, James N. Sleigh
Journal: Neuronal Signaling
Neuronal Signal (2023) 7 (1): NS20220098.
https://doi.org/10.1042/NS20220098
Published: 19 January 2023
View article titled, In vivo imaging of axonal transport in peripheral nerves of rodent forelimbs
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Includes: Supplementary data
Articles

Neural mechanisms of dopamine function in learning and memory in Caenorhabditis elegans

Open Access
Anna McMillen, Yee Lian Chew
Journal: Neuronal Signaling
Neuronal Signal (2024) 8 (1): NS20230057.
https://doi.org/10.1042/NS20230057
Published: 18 January 2023
View article titled, Neural mechanisms of dopamine function in learning and memory in Caenorhabditis elegans
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Articles

Amyloid-β in Alzheimer’s disease – front and centre after all?

Open Access
Caroline Weglinski, Alexander Jeans
Journal: Neuronal Signaling
Neuronal Signal (2023) 7 (1): NS20220086.
https://doi.org/10.1042/NS20220086
Published: 06 January 2023
View article titled, Amyloid-β in Alzheimer’s disease – front and centre after all?
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Articles

Celebrating 125 years of the synapse: from Sherrington to the present day

Open Access
In Collection
Celebrating 125 years of the Synapse
S Clare Stanford
Journal: Neuronal Signaling
Neuronal Signal (2022) 6 (4): NS20220015.
https://doi.org/10.1042/NS20220015
Published: 22 December 2022
View article titled, Celebrating 125 years of the synapse: from Sherrington to the present day
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Articles

The role of thalamic group II mGlu receptors in health and disease

Open Access
In Collection
Celebrating 125 years of the Synapse
Caroline S. Copeland, Thomas E. Salt
Journal: Neuronal Signaling
Neuronal Signal (2022) 6 (4): NS20210058.
https://doi.org/10.1042/NS20210058
Published: 15 November 2022
View article titled, The role of thalamic group II mGlu receptors in health and disease
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Articles

Introducing a new themed collection on emerging technologies for research models of human neuronal disorders in vivo and in vitro

Open Access
In Collection
Emerging technologies for research models of human neuronal disorders in vivo and in vitro
Thomas J. Cunningham, Clare Stanford
Journal: Neuronal Signaling
Neuronal Signal (2022) 6 (3): NS20220065.
https://doi.org/10.1042/NS20220065
Published: 30 September 2022
View article titled, Introducing a new themed collection on emerging technologies for research models of human neuronal disorders in vivo and in vitro
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Articles

Array tomography: 15 years of synaptic analysis

Open Access
In Collection
Celebrating 125 years of the Synapse
Anna Sanchez Avila, Christopher M. Henstridge
Journal: Neuronal Signaling
Neuronal Signal (2022) 6 (3): NS20220013.
https://doi.org/10.1042/NS20220013
Published: 23 September 2022
View article titled, Array tomography: 15 years of synaptic analysis
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Articles

Keeping synapses in shape: degradation pathways in the healthy and aging brain

Open Access
In Collection
Celebrating 125 years of the Synapse
Marijn Kuijpers
Journal: Neuronal Signaling
Neuronal Signal (2022) 6 (2): NS20210063.
https://doi.org/10.1042/NS20210063
Published: 15 June 2022
View article titled, Keeping synapses in shape: degradation pathways in the healthy and aging brain
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Articles

The synapse: people, words and connections

Open Access
In Collection
Celebrating 125 years of the Synapse
E. M. Tansey
Journal: Neuronal Signaling
Neuronal Signal (2022) 6 (2): NS20220017.
https://doi.org/10.1042/NS20220017
Published: 08 June 2022
View article titled, The synapse: people, words and connections
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Articles

Neuroligins in neurodevelopmental conditions: how mouse models of de novo mutations can help us link synaptic function to social behavior

Open Access
In Collection
Emerging technologies for research models of human neuronal disorders in vivo and in vitro , Celebrating 125 years of the Synapse
Tobias T. Pohl, Hanna Hörnberg
Journal: Neuronal Signaling
Neuronal Signal (2022) 6 (2): NS20210030.
https://doi.org/10.1042/NS20210030
Published: 10 May 2022
View article titled, Neuroligins in neurodevelopmental conditions: how mouse models of de novo mutations can help us link synaptic function to social behavior
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Articles

Targeting the M1 muscarinic acetylcholine receptor in Alzheimer’s disease

Open Access
Louis Dwomoh, Gonzalo S. Tejeda, Andrew B. Tobin
Journal: Neuronal Signaling
Neuronal Signal (2022) 6 (1): NS20210004.
https://doi.org/10.1042/NS20210004
Published: 21 April 2022
View article titled, Targeting the M1 muscarinic acetylcholine receptor in Alzheimer’s disease
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Articles

Insights into nervous system repair from the fruit fly

Open Access
In Collection
Emerging technologies for research models of human neuronal disorders in vivo and in vitro
David Coupe, Torsten Bossing
Journal: Neuronal Signaling
Neuronal Signal (2022) 6 (1): NS20210051.
https://doi.org/10.1042/NS20210051
Published: 13 April 2022
View article titled, Insights into nervous system repair from the fruit fly
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Articles

Cell models for Down syndrome-Alzheimer’s disease research

Open Access
In Collection
Emerging technologies for research models of human neuronal disorders in vivo and in vitro
Yixing Wu, Nicole R. West, Anita Bhattacharyya, Frances K. Wiseman
Journal: Neuronal Signaling
Neuronal Signal (2022) 6 (1): NS20210054.
https://doi.org/10.1042/NS20210054
Published: 08 April 2022
View article titled, Cell models for Down syndrome-Alzheimer’s disease research
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Articles

Neuroprotection of retinal ganglion cells in vivo using the activation of the endogenous cannabinoid signaling system in mammalian eyes

Open Access
Greg Maguire, Christy Eubanks, George Ayoub
Journal: Neuronal Signaling
Neuronal Signal (2022) 6 (1): NS20210038.
https://doi.org/10.1042/NS20210038
Published: 16 February 2022
View article titled, Neuroprotection of retinal ganglion cells in vivo using the activation of the endogenous cannabinoid signaling system in mammalian eyes
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Articles

Cholinergic blockade of neuroinflammation: from tissue to RNA regulators

Open Access
Tamara Zorbaz, Nimrod Madrer, Hermona Soreq
Journal: Neuronal Signaling
Neuronal Signal (2022) 6 (1): NS20210035.
https://doi.org/10.1042/NS20210035
Published: 11 February 2022
View article titled, Cholinergic blockade of neuroinflammation: from tissue to RNA regulators
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Articles

Sex-dependent effects of chronic exercise on cognitive flexibility but not hippocampal Bdnf in aging mice

Open Access
Annabel K. Short, Viet Bui, Isabel C. Zbukvic, Anthony J. Hannan, Terence Y. Pang, Jee Hyun Kim
Journal: Neuronal Signaling
Neuronal Signal (2022) 6 (1): NS20210053.
https://doi.org/10.1042/NS20210053
Published: 05 January 2022
View article titled, Sex-dependent effects of chronic exercise on cognitive flexibility but not hippocampal Bdnf in aging mice
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Articles

Do foetal transplant studies continue to be justified in Huntington’s disease?

Open Access
In Collection
Emerging technologies for research models of human neuronal disorders in vivo and in vitro
Oliver J.M. Bartley, Mariah J. Lelos, William P. Gray, Anne E. Rosser
Journal: Neuronal Signaling
Neuronal Signal (2021) NS20210019.
https://doi.org/10.1042/NS20210019
Published: 13 December 2021
View article titled, Do foetal transplant studies continue to be justified in Huntington’s disease?
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Articles

Animal models of Parkinson’s disease: a guide to selecting the optimal model for your research

Open Access
In Collection
Emerging technologies for research models of human neuronal disorders in vivo and in vitro
Joana Lama, Yazead Buhidma, Edward J.R. Fletcher, Susan Duty
Journal: Neuronal Signaling
Neuronal Signal (2021) 5 (4): NS20210026.
https://doi.org/10.1042/NS20210026
Published: 08 December 2021
View article titled, Animal models of Parkinson’s disease: a guide to selecting the optimal model for your research
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Articles

Mutations in DISC1 alter IP 3 R and voltage-gated Ca 2+ channel functioning, implications for major mental illness

Open Access
Ann R. Rittenhouse, Sonia Ortiz-Miranda, Agata Jurczyk
Journal: Neuronal Signaling
Neuronal Signal (2021) 5 (4): NS20180122.
https://doi.org/10.1042/NS20180122
Published: 07 December 2021
View article titled, Mutations in DISC1 alter IP 3 R and voltage-gated Ca 2+ channel functioning, implications for major mental illness
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Articles

Identification of TGFβ signaling as a regulator of interneuron neurogenesis in a human pluripotent stem cell model

Open Access
Maria Cruz Santos, Meng Li
Journal: Neuronal Signaling
Neuronal Signal (2021) 5 (4): NS20210020.
https://doi.org/10.1042/NS20210020
Published: 07 December 2021
View article titled, Identification of TGFβ signaling as a regulator of interneuron neurogenesis in a human pluripotent stem cell model
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Includes: Supplementary data
Articles

Molecular mechanisms of action of stimulant novel psychoactive substances that target the high-affinity transporter for dopamine

Open Access
Michelle A. Sahai, Jolanta Opacka-Juffry
Journal: Neuronal Signaling
Neuronal Signal (2021) 5 (4): NS20210006.
https://doi.org/10.1042/NS20210006
Published: 17 November 2021
View article titled, Molecular mechanisms of action of stimulant novel psychoactive substances that target the high-affinity transporter for dopamine
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Articles

3D hydrogel models of the neurovascular unit to investigate blood–brain barrier dysfunction

Open Access
In Collection
Emerging technologies for research models of human neuronal disorders in vivo and in vitro
Geoffrey Potjewyd, Katherine A.B. Kellett, Nigel M. Hooper
Journal: Neuronal Signaling
Neuronal Signal (2021) 5 (4): NS20210027.
https://doi.org/10.1042/NS20210027
Published: 09 November 2021
View article titled, 3D hydrogel models of the neurovascular unit to investigate blood–brain barrier dysfunction
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Articles

Super-resolution imaging to reveal the nanostructure of tripartite synapses

Open Access
Natalija Aleksejenko, Janosch P. Heller
Journal: Neuronal Signaling
Neuronal Signal (2021) 5 (4): NS20210003.
https://doi.org/10.1042/NS20210003
Published: 14 October 2021
View article titled, Super-resolution imaging to reveal the nanostructure of tripartite synapses
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Articles

Conventional protein kinase C in the brain: repurposing cancer drugs for neurodegenerative treatment?

Open Access
Gema Lordén, Alexandra C. Newton
Journal: Neuronal Signaling
Neuronal Signal (2021) 5 (4): NS20210036.
https://doi.org/10.1042/NS20210036
Published: 08 October 2021
View article titled, Conventional protein kinase C in the brain: repurposing cancer drugs for neurodegenerative treatment?
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Articles

A sticky situation: regulation and function of protein palmitoylation with a spotlight on the axon and axon initial segment

Open Access
Andrey A. Petropavlovskiy, Jordan A. Kogut, Arshia Leekha, Charlotte A. Townsend, Shaun S. Sanders
Journal: Neuronal Signaling
Neuronal Signal (2021) 5 (4): NS20210005.
https://doi.org/10.1042/NS20210005
Published: 06 October 2021
View article titled, A sticky situation: regulation and function of protein palmitoylation with a spotlight on the axon and axon initial segment
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Includes: Supplementary data
Articles

The immunogenicity of midbrain dopaminergic neurons and the implications for neural grafting trials in Parkinson’s disease

Open Access
Shamma Qarin, Sarah K. Howlett, Joanne L. Jones, Roger A. Barker
Journal: Neuronal Signaling
Neuronal Signal (2021) 5 (3): NS20200083.
https://doi.org/10.1042/NS20200083
Published: 13 September 2021
View article titled, The immunogenicity of midbrain dopaminergic neurons and the implications for neural grafting trials in Parkinson’s disease
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Articles

Anti-inflammatory cytokine-eluting collagen hydrogel reduces the host immune response to dopaminergic cell transplants in a rat model of Parkinson’s disease

Open Access
Sílvia Cabré, Verónica Alamilla, Niamh Moriarty, Abhay Pandit, Eilís Dowd
Journal: Neuronal Signaling
Neuronal Signal (2021) 5 (3): NS20210028.
https://doi.org/10.1042/NS20210028
Published: 23 August 2021
View article titled, Anti-inflammatory cytokine-eluting collagen hydrogel reduces the host immune response to dopaminergic cell transplants in a rat model of Parkinson’s disease
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Articles

Oligodendrocytes in the aging brain

Open Access
Eleanor Catherine Sams
Journal: Neuronal Signaling
Neuronal Signal (2021) 5 (3): NS20210008.
https://doi.org/10.1042/NS20210008
Published: 06 July 2021
View article titled, Oligodendrocytes in the aging brain
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Articles

α-synuclein pathogenesis in hiPSC models of Parkinson’s disease

Open Access
In Collection
Emerging technologies for research models of human neuronal disorders in vivo and in vitro
Jara M. Baena-Montes, Sahar Avazzadeh, Leo R. Quinlan
Journal: Neuronal Signaling
Neuronal Signal (2021) 5 (2): NS20210021.
https://doi.org/10.1042/NS20210021
Published: 23 June 2021
View article titled, α-synuclein pathogenesis in hiPSC models of Parkinson’s disease
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Articles

Exploiting the neuroprotective effects of α-klotho to tackle ageing- and neurodegeneration-related cognitive dysfunction

Open Access
Kelsey Hanson, Kate Fisher, Nigel M. Hooper
Journal: Neuronal Signaling
Neuronal Signal (2021) 5 (2): NS20200101.
https://doi.org/10.1042/NS20200101
Published: 14 June 2021
View article titled, Exploiting the neuroprotective effects of α-klotho to tackle ageing- and neurodegeneration-related cognitive dysfunction
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Articles

Back to the future: lessons from past viral infections and the link with Parkinson’s disease

Open Access
In Collection
Coronavirus
Eilis Dowd, Declan P. McKernan
Journal: Neuronal Signaling
Neuronal Signal (2021) 5 (1): NS20200051.
https://doi.org/10.1042/NS20200051
Published: 16 April 2021
View article titled, Back to the future: lessons from past viral infections and the link with Parkinson’s disease
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Articles

Signalling pathways contributing to learning and memory deficits in the Ts65Dn mouse model of Down syndrome

Open Access
Aimée Freeburn, Robert Gordon Keith Munn
Journal: Neuronal Signaling
Neuronal Signal (2021) 5 (1): NS20200011.
https://doi.org/10.1042/NS20200011
Published: 12 March 2021
View article titled, Signalling pathways contributing to learning and memory deficits in the Ts65Dn mouse model of Down syndrome
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Articles

The life cycle of voltage-gated Ca 2+ channels in neurons: an update on the trafficking of neuronal calcium channels

Open Access
Laurent Ferron, Saloni Koshti, Gerald W. Zamponi
Journal: Neuronal Signaling
Neuronal Signal (2021) 5 (1): NS20200095.
https://doi.org/10.1042/NS20200095
Published: 23 February 2021
View article titled, The life cycle of voltage-gated Ca 2+ channels in neurons: an update on the trafficking of neuronal calcium channels
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Articles

Neuronal Signaling : A reflection on the Biochemical Society’s newest journal and an exciting outlook on its next steps

Open Access
Aideen M. Sullivan, S. Clare Stanford
Journal: Neuronal Signaling
Neuronal Signal (2021) 5 (1): NS20210007.
https://doi.org/10.1042/NS20210007
Published: 08 February 2021
View article titled, Neuronal Signaling : A reflection on the Biochemical Society’s newest journal and an exciting outlook on its next steps
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Articles

Neuroprotective function of microglia in the developing brain

Open Access
Yuki Fujita, Toshihide Yamashita
Journal: Neuronal Signaling
Neuronal Signal (2021) 5 (1): NS20200024.
https://doi.org/10.1042/NS20200024
Published: 22 January 2021
View article titled, Neuroprotective function of microglia in the developing brain
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Includes: Supplementary data
Articles

Exercise alters LPS-induced glial activation in the mouse brain

Open Access
Bibiana C. Mota, Áine M. Kelly
Journal: Neuronal Signaling
Neuronal Signal (2020) 4 (4): NS20200003.
https://doi.org/10.1042/NS20200003
Published: 02 December 2020
View article titled, Exercise alters LPS-induced glial activation in the mouse brain
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Articles

Lactobacillus rhamnosus GG soluble mediators ameliorate early life stress-induced visceral hypersensitivity and changes in spinal cord gene expression

Open Access
Karen-Anne McVey Neufeld, Conall R. Strain, Matteo M. Pusceddu, Rosaline V. Waworuntu, Sarmauli Manurung, Gabriele Gross, Gerry M. Moloney, Alan E. Hoban, Kiera Murphy, Catherine Stanton, Timothy G. Dinan, John F. Cryan, Siobhain M. O'Mahony
Journal: Neuronal Signaling
Neuronal Signal (2020) 4 (4): NS20200007.
https://doi.org/10.1042/NS20200007
Published: 23 November 2020
View article titled, Lactobacillus rhamnosus GG soluble mediators ameliorate early life stress-induced visceral hypersensitivity and changes in spinal cord gene expression
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Includes: Supplementary data
Articles

Auditory fear conditioning alters neural gain in the cochlear nucleus: a wireless neural recording study in freely behaving rats

Open Access
Antonio G. Paolini, Simeon J. Morgan, Jee Hyun Kim
Journal: Neuronal Signaling
Neuronal Signal (2020) 4 (4): NS20200009.
https://doi.org/10.1042/NS20200009
Published: 16 November 2020
View article titled, Auditory fear conditioning alters neural gain in the cochlear nucleus: a wireless neural recording study in freely behaving rats
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Articles

New developments in Huntington’s disease and other triplet repeat diseases: DNA repair turns to the dark side

Open Access
Robert S. Lahue
Journal: Neuronal Signaling
Neuronal Signal (2020) 4 (4): NS20200010.
https://doi.org/10.1042/NS20200010
Published: 16 November 2020
View article titled, New developments in Huntington’s disease and other triplet repeat diseases: DNA repair turns to the dark side
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Articles

MEF2C and HDAC5 regulate Egr1 and Arc genes to increase dendritic spine density and complexity in early enriched environment

Open Access
Shu Juan Puang, Bavani Elanggovan, Tendy Ching, Judy C.G. Sng
Journal: Neuronal Signaling
Neuronal Signal (2020) 4 (3): NS20190147.
https://doi.org/10.1042/NS20190147
Published: 23 July 2020
View article titled, MEF2C and HDAC5 regulate Egr1 and Arc genes to increase dendritic spine density and complexity in early enriched environment
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Includes: Supplementary data
Articles

The class II histone deacetylases as therapeutic targets for Parkinson’s disease

Open Access
Martina Mazzocchi, Louise M Collins, Aideen M. Sullivan, Gerard W. O'Keeffe
Journal: Neuronal Signaling
Neuronal Signal (2020) 4 (2): NS20200001.
https://doi.org/10.1042/NS20200001
Published: 09 June 2020
View article titled, The class II histone deacetylases as therapeutic targets for Parkinson’s disease
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