...Nicolas Dzamko The contribution of the immune system to the pathophysiology of neurodegenerative Parkinson’s disease (PD) is increasingly being recognised, with alterations in the innate and adaptive arms of the immune system underlying central and peripheral inflammation in PD. As chief modulators...

...Chiara Domenicale; Stefano Magnabosco; Michele Morari Mutations in the leucine-rich repeat kinase 2 ( LRRK2 ) gene are associated with familial and sporadic forms of Parkinson’s disease (PD). Sporadic PD and LRRK2 PD share main clinical and neuropathological features, namely hypokinesia...

...Martina Mazzocchi; Louise M Collins; Aideen M. Sullivan; Gerard W. O'Keeffe Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterised by specific motor impairments. The neuropathological hallmarks of PD include progressive degeneration of midbrain dopaminergic neurons...

... domain, and several repeat domains. LRRK2 is genetically involved in the pathogenesis of both sporadic and familial Parkinson’s disease (FPD). Parkinson’s disease (PD) is the second most common neurodegenerative disorder, manifesting progressive motor dysfunction. PD is pathologically characterized...

...Laura K. Olsen; Eilis Dowd; Declan P. McKernan Despite over 200 years since its first description by James Parkinson, the cause(s) of most cases of Parkinson’s disease (PD) are yet to be elucidated. The disparity between the current understanding of PD symptomology and pathology has led to numerous...