..., degeneration of nigro-striatal dopamine neurons and α-synuclein aggregates in the form of Lewy bodies. Animals harboring the most common LRRK2 mutations, i.e. p.G2019S and p.R1441C/G, have been generated to replicate the parkinsonian phenotype and investigate the underlying pathogenic mechanisms...

...Anna McMillen; Yee Lian Chew Research into learning and memory over the past decades has revealed key neurotransmitters that regulate these processes, many of which are evolutionarily conserved across diverse species. The monoamine neurotransmitter dopamine is one example of this, with countless...

...+ neurons in cultures of E14 rat VM. Scale bar as indicated. axon dopamine microRNA Parkinson’s disease (PD) is the second most common neurodegenerative disease that presents with both motor and non-motor symptoms, and occurs in 1–2% of people over the age of 65 [ 1 ]. PD is characterized...

... dopamine neuron neuroprotection neurotrophic factor Parkinson's disease Smad Dopamine is one of the major catecholaminergic neurotransmitters found in the adult brain. Seventy-five percent of all dopaminergic neurons are found in the midbrain, with an estimated 400000 to 600000 in the human...