... neurodegeneration starts but is functionally compensated, followed by a prodromal/premotor phase, where non-motor symptoms such as REM behavior sleep disorders (RBD), depression and hyposmia emerge, and a motor phase where classical hypokinetic symptoms appear and clinical diagnosis is made [ 1 , 3 ]. The etiology...

... 2022 The Author(s). 2022 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . cannabinoids glutamate neurodegeneration Retina Ten days later, mice were...

... stem cells neurodegeneration stroke Correspondence: Nigel M. Hooper ( [email protected] ) 16 08 2021 20 10 2021 22 10 2021 01 11 2021 © 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf...

... with neurodegeneration. Gain-of-function mutations in PKCα are associated with Alzheimer’s disease (AD) and mutations in PKCγ cause spinocerebellar ataxia (SCA) type 14 (SCA14). This article presents an overview of the role of the conventional PKCα and PKCγ in neurodegeneration and proposes repurposing PKC inhibitors...

... the recent research on neuronal α-klotho and discuss how the neuroprotective properties of α-klotho could be exploited to tackle age- and neurodegeneration-associated cognitive dysfunction. Correspondence: Kelsey Hanson ( [email protected] ) or Nigel M. Hooper ( nigel.hooper...

... and neurodegeneration in PD, and review the recent literature on SARS infections, the potential link with PD and the potential areas of study in the future. Correspondence: Declan P. McKernan ( [email protected] ) 27 11 2020 30 03 2021 31 03 2021 09 04 2021 © 2021 The Author...

... License 4.0 (CC BY) . Open access for this article was enabled by the participation of University College London in an all-inclusive Read & Publish pilot with Portland Press and the Biochemical Society under a transformative agreement with JISC. neurodegeneration neuroscience signalling...

... synthesis and repair genome integrity mutation neurodegeneration The main purpose of this review is to provide an overview of recent developments in the role of DNA repair in Huntington’s disease (HD) and other triplet repeat diseases. The review is primarily intended for neurobiologists, physicians...

... unique logistical challenges and must sustain homoeostasis over decades. Defective autophagy has pathophysiological importance, especially for human neurodegeneration. The present-day definition of autophagy broadly encompasses two distinct yet related phenomena: non-selective and selective autophagy...

... processes and the accumulation of dysfunctional mitochondria may be the main cause of neuronal death and lead to neurodegeneration. Here, we focus on the inseparable relationship of mitochondria dynamics and mitophagy and how their dysfunction may lead to neurodegenerative diseases. Correspondence...

... This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . calcium homoeostasis mitochondrial permeability transition pore mitochondria neurodegeneration Calcium is used...

... phosphorylation of these substrates is the cause of the neurodegeneration in PD. In this review, we summarize latest findings regarding the physiological and pathological functions of LRRK2, and discuss the possible molecular mechanisms of neurodegeneration caused by LRRK2 and its substrates. * These authors...

... mediators results in dopaminergic neurodegeneration [ 112 , 113 ]. Examination of the TLR profile in animal models found increases in TLR3/4 expression in the striatum in response to OS and the pesticide rotenone, possibly leaving these cell populations/brain regions more sensitive to an infection [ 114...

... is associated with neurodegeneration. This review presents an overview of signaling by diacylglycerol (DG)-dependent PKC isozymes in the brain, and focuses on the role of the Ca 2+ -sensitive conventional PKC isozymes in neurodegeneration. Alzheimer's disease neurodegeneration posttranslational...