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Articles
Journal:
Biochemical Journal
Biochem J (1975) 146 (3): 537–547.
Published: 01 March 1975
...R G Hansford 1. A study is presented of the mitochondrial NADH content during controlled (state 4) and active (state 3) pyruvate oxidation by blowfly flight-muscle mitochondria. The results confirm and extend those of an earlier study (Hansford, 1972), which indicated an increased reduction...
Articles
Journal:
Biochemical Journal
Biochem J (2004) 382 (2): 527–533.
Published: 24 August 2004
...Clara BIONDA; Jacques PORTOUKALIAN; Daniel SCHMITT; Claire RODRIGUEZ-LAFRASSE; Dominique ARDAIL Recent studies by our group and others have disclosed the presence of ceramides in mitochondria, and the activities of ceramide synthase and reverse ceramidase in mitochondria have also been reported...
Articles
James A. HARPER, Jeff A. STUART, Mika B. JEKABSONS, Damien ROUSSEL, Kevin M. BRINDLE, Keith DICKINSON, Robert B. JONES, Martin D. BRAND
Journal:
Biochemical Journal
Biochem J (2002) 361 (1): 49–56.
Published: 17 December 2001
...James A. HARPER; Jeff A. STUART; Mika B. JEKABSONS; Damien ROUSSEL; Kevin M. BRINDLE; Keith DICKINSON; Robert B. JONES; Martin D. BRAND Western blots detected uncoupling protein 3 (UCP3) in skeletal-muscle mitochondria from wild-type but not UCP3 knock-out mice. Calibration with purified...
Articles
Journal:
Biochemical Journal
Biochem J (1998) 331 (1): 217–223.
Published: 01 April 1998
...Young-Ji SHIAO; Bénédicte BALCERZAK; Jean E. VANCE The mechanism of import of phosphatidylserine (PtdSer) into mitochondria was investigated using a reconstituted system of isolated organelles in vitro in which PtdSer was translocated from donor membranes to mitochondria and was decarboxylated...
Articles
Journal:
Bioscience Reports
Biosci Rep (1997) 17 (6): 507–520.
Published: 01 December 1997
...Dmitry B. Zorov; Boris F. Krasnikov; Alevtina E. Kuzminova; Michail Yu. Vysokikh; Ljubava D. Zorova This review explores the alternative functions of mitochondria inside the cell. In a general picture of mitochondrial functioning, the importance and uniqueness of these intrinsic functions make them...
Articles
Journal:
Biochemical Journal
Biochem J (1986) 239 (1): 31–40.
Published: 01 October 1986
...I Al-Nasser; M Crompton The permeabilization-resealing technique [Al-Nasser & Crompton, Biochem. J. (1986) 239, 19-29] has been applied to the entrapment of arsenazo III in the matrix compartment of rat liver mitochondria. The addition of 10 mM-arsenazo III to mitochondria permeabilized...
Articles
Journal:
Biochemical Journal
Biochem J (1984) 221 (1): 147–152.
Published: 01 July 1984
...D E Whipps; A P Halestrap Liver mitochondria isolated from glucagon-treated rats by using both mannitol- and sucrose-based media showed enhanced uncoupled succinate oxidation, pyruvate metabolism and citrulline synthesis. Mitochondria prepared in mannitol medium showed some stimulation...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (1979) 7 (1): 258–259.
Published: 01 February 1979
...D. LLOYD Mitochondria 1977: Genetics and Biogenesis of Mitochondria BANDLOW W. SCHWEYEN R. J. WOLF K. KAUDEWITZ F. Walter de Gruyter Berlin and New York 1977 pp. 669, DM. 190.00 © 1979 Biochemical Society 1979 Book Reviews 258 BIOCHEMICAL SOCIETY...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (1974) 2 (6): 1285–1286.
Published: 01 December 1974
..., 1246 Thompson, E. H., Allen, C. E. & Mead, R. J. (1973) J. Anim. Sci. 36,868-873 Wahle, K. W. J. (1974) Comp. Biochem. Physiol. 48,87-106 Williams, R . B. & Mills, C. F. (1970) Brit. J. Nutr. 24, 989-1003 Exchange of the Endogenous Carnitine of Ox Heart Mitochondria with External Carnitine and its...
Articles
Journal:
Biochemical Journal
Biochem J (1974) 144 (3): 551–558.
Published: 01 December 1974
...R F W Thorne; F L Bygrave Cyclic stimulation by Ca 2+ of respiration in mitochondria isolated from Ehrlich ascites-tumour cells occurs only when low phosphate concentrations (approx. 0.5m m ) are also included in the incubation system. Under these circumstances the extra oxygen consumed is related...
Articles
Journal:
Biochemical Journal
Biochem J (1973) 134 (4): 935–947.
Published: 01 August 1973
...J. M. Haslam; Margaret Perkins; Anthony W. Linnane 1. Parameters of ATP uptake by fully functional Saccharomyces cerevisiae mitochondria, including kinetic constants, binding constants and sensitivity to atractylate, closely resemble those of mammalian mitochondria. Scatchard plots of atractylate...
Articles
Journal:
Biochemical Journal
Biochem J (1973) 134 (4): 949–957.
Published: 01 August 1973
...J. M. Haslam; T. W. Spithill; Anthony W. Linnane; J. B. Chappell 1. The fatty acid composition of the membrane lipids of a fatty acid desaturase mutant of Saccharomyces cerevisiae was manipulated by growing the organism in a medium containing defined fatty acid supplements. 2. Mitochondria were...
Articles
Journal:
Biochemical Journal
Biochem J (1971) 124 (2): 327–336.
Published: 01 September 1971
.... The mitochondria–synaptosome fraction synthesized protein in vitro by a route that was partially inhibited by cycloheximide and partly by chloramphenicol. The relative effectiveness of the two inhibitors varied greatly with the medium used. In the mitochondria–synaptosome fraction active 80S cytoplasmic ribosomes...
Articles
Journal:
Biochemical Journal
Biochem J (1970) 117 (5): 861–877.
Published: 01 May 1970
... synthetase (1.0), aspartate aminotransferase (1.7), alanine aminotransferase (6.1). The mean DNA content of eight preparations of fat-cells was 109μg/g dry weight of cells. 2. Mitochondria showing respiratory control ratios of 3–6 with pyruvate, about 3 with succinate and P/O ratios of approaching 3 and 2...
Articles
Journal:
Biochemical Journal
Biochem J (1965) 94 (2): 494–501.
Published: 01 February 1965
...KB FREEMAN © 1965 The Biochemical Society 1965 Biochem. J. (1965) 94, 494 Protein Synthesis in Mitochondria 4. PREPARATION AND PROPERTIES OF MITOCHONDRIA FROM KREBS II MOUSE ASCITES-TUMOUR CELLS* By K. B. FREEMAN National Institute for Medical Research, Mill Hill, London, N. W. 7 (Received 8...
Articles
Journal:
Biochemical Journal
Biochem J (1962) 85 (1): 177–189.
Published: 01 October 1962
.... Smithies, 0. (1959). Advanc. Protein Chem. 16, 76. Velick, S. F. (1949). J. phys. Colloid Chem. 53, 135. Biochem. J. (1962) 85, 177 Protein Synthesis in Mitochondria 3. THE CONTROLLED DISRUPTION AND SUBFRACTIONATION OF MITOCHONDRIA LABELLED IN VITRO WITH RADIOACTIVE VALINE* BY D. B. ROODYN National...
Articles
Anastasia S. Shulha, Vita Shyshenko, Ryan S. Schibalski, Adam C. Jones, Jessica L. Faulkner, Krisztian Stadler, Daria V. Ilatovskaya
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2024) 52 (6): 2307–2319.
Published: 27 November 2024
... in mitochondrial bioenergetics in health and disease are concerned. This manuscript provides an overview of the new evidence that has been accumulated regarding the role of sex hormones in renal and cardiac mitochondria-dependent cellular energetics, metabolism, and signaling, mainly focusing on the data obtained...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2024) 138 (15): 963–973.
Published: 30 July 2024
... of STCs ameliorates renal injury and dysfunction in murine models of acute kidney injury, underscoring the regenerative potential of this endogenous repair system. Although STCs contain fewer mitochondria than their surrounding terminally differentiated tubular epithelial cells, these organelles modulate...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2024) 52 (3): 1305–1315.
Published: 08 May 2024
...Fabio Ciccarone; Maria Rosa Ciriolo Mitochondria represent the metabolic hub of normal cells and play this role also in cancer but with different functional purposes. While cells in differentiated tissues have the prerogative of maintaining basal metabolism and support the biosynthesis...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2024) 52 (2): 911–922.
Published: 17 April 2024
...Stephan Nussberger; Robin Ghosh; Shuo Wang To date, there is no general physical model of the mechanism by which unfolded polypeptide chains with different properties are imported into the mitochondria. At the molecular level, it is still unclear how transit polypeptides approach, are captured...
Includes: Supplementary data
Articles
In Collection
Cell signaling in the 21st century
Journal:
Biochemical Journal
Biochem J (2023) 480 (13): 909–919.
Published: 04 July 2023
..., and hence contribute to pathophysiological states. Therefore, it is not surprising that mitochondria have emerged as being pivotal in maintaining physiological homeostasis through daily oscillations/fluctuations in nutrient inputs and light–dark/sleep–wake cycles. Moreover, given the inherent association...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (2): 571–577.
Published: 09 March 2023
...Margret Helene Bülow; Julia Sellin The study of endoplasmic reticulum (ER)-mitochondria communication is a vast and expanding field with many novel developments in the past few years. In this mini-review, we focus on several recent publications that identify novel functions of tether complexes...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2023) 137 (3): 219–237.
Published: 02 February 2023
... that mitochondria, the central players in cellular iron utilisation, are dysfunctional in respiratory cells in individuals with COPD, with alterations in mitochondrial bioenergetics and dynamics driving disease progression. Understanding the molecular mechanisms underlying the dysfunction of mitochondria...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (1): 173–182.
Published: 23 January 2023
...Heather M. Wilkins Mitochondrial dysfunction and Aβ accumulation are hallmarks of Alzheimer's disease (AD). Decades of research describe a relationship between mitochondrial function and Aβ production. Amyloid precursor protein (APP), of which Aβ is generated from, is found within mitochondria...
Articles
Structural functionality of skeletal muscle mitochondria and its correlation with metabolic diseases
Journal:
Clinical Science
Clin Sci (Lond) (2022) 136 (24): 1851–1871.
Published: 22 December 2022
... a high level of metabolic flexibility, which is reduced in several metabolic diseases, including obesity and Type 2 diabetes (T2D). Skeletal muscle health is highly dependent on optimally functioning mitochondria that exist in a highly integrated network with the sarcoplasmic reticulum and sarcolemma...
Articles
Paul T. Morse, Junmei Wan, Jamie Bell, Icksoo Lee, Dennis J. Goebel, Moh H. Malek, Thomas H. Sanderson, Maik Hüttemann
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (5): 1377–1388.
Published: 06 September 2022
... restoration of blood flow is necessary to save brain tissue, it also causes reperfusion injury. Mitochondria play a crucial role in early ischemia-reperfusion injury due to the generation of reactive oxygen species (ROS). During ischemia, mitochondria sense energy depletion and futilely attempt to up-regulate...
Articles
Journal:
The Biochemist
Biochem (Lond) (2022) 44 (4): 1.
Published: 30 August 2022
...Heather Doran Correspondence: Heather Doran ( [email protected] ) © Biochemical Society 2022 In this issue of The Biochemist , we are bringing you articles that cover all the things that you didn’t know about mitochondria. We all know the definition of mitochondria...
Articles
Journal:
The Biochemist
Biochem (Lond) (2022) 44 (4): 2–8.
Published: 23 August 2022
...Ram Prosad Chakrabarty; Navdeep S. Chandel Mitochondria, special double-membraned intracellular compartments or ‘organelles’, are popularly known as the ‘powerhouses of the cell’, as they generate the bulk of ATP used to fuel cellular biochemical reactions. Mitochondria are also well known...
Articles
Journal:
The Biochemist
Biochem (Lond) (2022) 44 (4): 22–28.
Published: 04 August 2022
...Elio Caccavale; Michael Pierre Johnson; Sonya Brijbassi; Ana C. Andreazza; Kostas Tokatlidis The ‘Mitochondria and Us’ project embodies our ambition to break new ground by working across traditionally siloed disciplines and by co-creating innovative approaches to impact research and societal...
Articles
Journal:
The Biochemist
Biochem (Lond) (2022) 44 (4): 14–18.
Published: 01 August 2022
...Martin Picard The body and mind are fuelled by energy. But where does the energy come from? The sun beams energy through space as photons that are captured by plants, which store that energy in the improbable separation of carbon and oxygen. By reuniting carbon and oxygen in their mitochondria...
Articles
Journal:
Bioscience Reports
Biosci Rep (2022) 42 (1): BSR20211464.
Published: 06 January 2022
..., which induced membrane blebbing in some cells, the localization appeared to be correlated more with the mitochondria in these cells. It is yet to be determined whether this translocation is part of the cytoprotective mechanism or a consequence of chemically induced cell stress. apoptosis calcium...
Articles
Journal:
Biochemical Journal
Biochem J (2021) 478 (16): 3125–3143.
Published: 26 August 2021
...Fabian den Brave; Jeannine Engelke; Thomas Becker Mitochondria import about 1000 proteins that are produced as precursors on cytosolic ribosomes. Defects in mitochondrial protein import result in the accumulation of non-imported precursor proteins and proteotoxic stress. The cell is equipped...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (14): 1767–1772.
Published: 27 July 2021
...) mitochondria in a sex-dependent fashion with a greater effect on male fetuses, although mitochondrial transcripts increased more so in females. Increased expression for several respiratory chain and adenosine triphosphate (ATP) synthase proteins were observed. However, fetal LV mitochondrial complex I...
Articles
Susana P. Pereira, Ludgero C. Tavares, Ana I. Duarte, Inês Baldeiras, Teresa Cunha-Oliveira, João D. Martins, Maria S. Santos, Alina Maloyan, António J. Moreno, Laura A. Cox, Cun Li, Peter W. Nathanielsz, Mark J. Nijland, Paulo J. Oliveira
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (9): 1103–1126.
Published: 11 May 2021
... development, predisposing offspring to cardiometabolic diseases. The role of mitochondria during fetal development on later-life cardiac dysfunction caused by maternal nutrient reduction (MNR) remains unexplored. We hypothesized that MNR during gestation causes fetal cardiac bioenergetic deficits...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2021) 478 (4): 749–764.
Published: 24 February 2021
... influence of cocaine, respectively. Inset: chemical structure of cocaine, a weak base. TCA, tricarboxylic acid cycle; mtDNA, mitochondrial DNA. In mitochondria, the production of ATP by oxidative phosphorylation depends on the efficient functioning of the electron transport chain (ETC) complexes I–IV...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (4): 593–595.
Published: 18 February 2021
...Shaimaa Nasr Amin This commentary highlights the research entitled: Transplantation of platelet-derived mitochondria alleviates cognitive impairment and mitochondrial dysfunction in db/db mice, presented by Ma et al. appearing in Clinical Science (2020) 134 (16), https://doi.org/10.1042/CS20200530...
Articles
Journal:
Bioscience Reports
Biosci Rep (2021) 41 (1): BSR20203481.
Published: 27 January 2021
...Li-rong Yan; Ang Wang; Zhi Lv; Yuan Yuan; Qian Xu Background: Mitochondria-nuclear cross-talk and mitochondrial retrograde regulation are involved in the genesis and development of breast cancer (BC). Therefore, mitochondria can be regarded as a promising target for BC therapeutic strategies...
Includes: Supplementary data
Articles
Giulia Pinto, Inés Saenz-de-Santa-Maria, Patricia Chastagner, Emeline Perthame, Caroline Delmas, Christine Toulas, Elizabeth Moyal-Jonathan-Cohen, Christel Brou, Chiara Zurzolo
Journal:
Biochemical Journal
Biochem J (2021) 478 (1): 21–39.
Published: 08 January 2021
... and in 3D-tumor organoids, formed functional TNTs which allowed mitochondria transfer. In the organoid model, recapitulative of several tumor's features, we observed the formation of a network between cells constituted of both Tumor Microtubes (TMs), previously observed in vivo , and TNTs. In addition...
Includes: Multimedia, Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (1): 109–126.
Published: 06 January 2021
... deposition and NFTs formation in AD, such as aberrant calcium homeostasis, abnormal lipid metabolism, mitochondrial dysfunction and autophagy. Notably, these earlier pathologies are closely associated with mitochondria-associated membranes (MAMs), the physical structures connecting the endoplasmic reticulum...
Articles
Hongli Ma, Tao Jiang, Wenxin Tang, Zhi Ma, Kairui Pu, Fuxing Xu, Haiqing Chang, Ge Zhao, Wei Gao, Yansong Li, Qiang Wang
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (16): 2161–2175.
Published: 24 August 2020
...Hongli Ma; Tao Jiang; Wenxin Tang; Zhi Ma; Kairui Pu; Fuxing Xu; Haiqing Chang; Ge Zhao; Wei Gao; Yansong Li; Qiang Wang Diabetes-associated cognitive impairment (DACI) can increase the risk of major cardiovascular events and death. Neuronal functionality is highly dependent on mitochondria...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2020) 477 (8): 1515–1524.
Published: 29 April 2020
... ). Moreover, PolyP can stimulate F 0 F 1 -ATPase activity in the presence of ATP and, importantly, can be hydrolyzed in this enzyme instead of ATP. Furthermore, PolyP can be produced in mitochondria in the presence of substrates for respiration and phosphate by the F 0 F 1 -ATPsynthase. Thus, polyP...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (7): 885–888.
Published: 14 April 2020
...Fouad A. Zouein; George W. Booz Mitochondria are dynamic, undergoing both fission and fusion. Evidence indicates that a balance between these two processes is necessary to maintain a healthy state. With ischemia/reperfusion (I/R) of the heart, fission is enhanced and is associated...
Articles
Milad Ashrafizadeh, Sara Javanmardi, Masoumeh Moradi-Ozarlou, Reza Mohammadinejad, Tahereh Farkhondeh, Saeed Samarghandian, Manoj Garg
Journal:
Bioscience Reports
Biosci Rep (2020) 40 (4): BSR20200257.
Published: 03 April 2020
...Milad Ashrafizadeh; Sara Javanmardi; Masoumeh Moradi-Ozarlou; Reza Mohammadinejad; Tahereh Farkhondeh; Saeed Samarghandian; Manoj Garg Mitochondria are intracellular organelles with two distinct membranes, known as an outer mitochondrial membrane and inner cell membrane. Originally, mitochondria...
Articles
Journal:
Biochemical Journal
Biochem J (2019) 476 (8): 1267–1284.
Published: 26 April 2019
...Heejeong Lee; Jae Sam Hwang; Dong Gun Lee Communications between various organelle–organelles play an essential role in cell survival. The cross-talk between mitochondria and vacuoles comes up with the vital roles of the intercompartmental process. In this study, we found a couple of cell death...
Articles
In Collection
Editors' pick of review article highlights published in the Biochemical Journal in 2018 & 2019
Journal:
Biochemical Journal
Biochem J (2018) 475 (14): 2305–2328.
Published: 31 July 2018
.... Tunneling nanotubes (TNTs) are newly discovered long-range intercellular connections that allow the exchange between cells of various cargos, ranging from ions to whole organelles such as mitochondria. TNT-transferred mitochondria were shown to change the metabolism and functional properties of recipient...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2018) 46 (4): 891–909.
Published: 19 July 2018
...Ruby Macdonald; Katy Barnes; Christopher Hastings; Heather Mortiboys Mitochondrial abnormalities have been identified as a central mechanism in multiple neurodegenerative diseases and, therefore, the mitochondria have been explored as a therapeutic target. This review will focus on the evidence...
Articles
Journal:
Bioscience Reports
Biosci Rep (2018) 38 (3): BSR20180208.
Published: 29 June 2018
...María Cecilia De Rossi; Valeria Levi; Luciana Bruno Molecular motors play relevant roles on the regulation of mitochondria size and shape, essential properties for the cell homeostasis. In this work, we tracked single rod-shaped mitochondria with nanometer precision to explore the performance...
Includes: Multimedia, Supplementary data
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2018) 46 (2): 437–452.
Published: 27 March 2018
...Francesca Giordano Mitochondria are highly dynamic organelles involved in various cellular processes such as energy production, regulation of calcium homeostasis, lipid trafficking, and apoptosis. To fulfill all these functions and preserve their morphology and dynamic behavior, mitochondria need...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2018) 46 (2): 295–309.
Published: 27 February 2018
... Correspondence: Alexander K.H. Weiss ( [email protected] ) 31 10 2017 23 12 2017 2 1 2018 In eukaryotes, nutrient-derived PYR is imported to the mitochondria where it is oxidized by the pyruvate dehydrogenase complex (PDH) to acetyl-CoA ( Figure 2A ). Acetyl-CoA enters the TCA...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2018) 475 (2): 495–509.
Published: 31 January 2018
...Inga Kruse; Andrew E. Maclean; Lionel Hill; Janneke Balk Mitochondria play a key role in the biosynthesis of two metal cofactors, iron–sulfur (FeS) clusters and molybdenum cofactor (Moco). The two pathways intersect at several points, but a scarcity of mutants has hindered studies to better...
Includes: Supplementary data
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