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mitochondria

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Biochem J (1975) 146 (3): 537–547.
Published: 01 March 1975
...R G Hansford 1. A study is presented of the mitochondrial NADH content during controlled (state 4) and active (state 3) pyruvate oxidation by blowfly flight-muscle mitochondria. The results confirm and extend those of an earlier study (Hansford, 1972), which indicated an increased reduction...
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Biosci Rep (1997) 17 (6): 507–520.
Published: 01 December 1997
...Dmitry B. Zorov; Boris F. Krasnikov; Alevtina E. Kuzminova; Michail Yu. Vysokikh; Ljubava D. Zorova This review explores the alternative functions of mitochondria inside the cell. In a general picture of mitochondrial functioning, the importance and uniqueness of these intrinsic functions make them...
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Biochem Soc Trans (1979) 7 (1): 258–259.
Published: 01 February 1979
...D. LLOYD Mitochondria 1977: Genetics and Biogenesis of Mitochondria BANDLOW W. SCHWEYEN R. J. WOLF K. KAUDEWITZ F. Walter de Gruyter Berlin and New York 1977 pp. 669, DM. 190.00 © 1979 Biochemical Society 1979 Book Reviews 258 BIOCHEMICAL SOCIETY...
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Biochem J (2023) 480 (13): 909–919.
Published: 04 July 2023
..., and hence contribute to pathophysiological states. Therefore, it is not surprising that mitochondria have emerged as being pivotal in maintaining physiological homeostasis through daily oscillations/fluctuations in nutrient inputs and light–dark/sleep–wake cycles. Moreover, given the inherent association...
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Biochem Soc Trans (2023) 51 (2): 571–577.
Published: 09 March 2023
...Margret Helene Bülow; Julia Sellin The study of endoplasmic reticulum (ER)-mitochondria communication is a vast and expanding field with many novel developments in the past few years. In this mini-review, we focus on several recent publications that identify novel functions of tether complexes...
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Clin Sci (Lond) (2023) 137 (3): 219–237.
Published: 02 February 2023
... that mitochondria, the central players in cellular iron utilisation, are dysfunctional in respiratory cells in individuals with COPD, with alterations in mitochondrial bioenergetics and dynamics driving disease progression. Understanding the molecular mechanisms underlying the dysfunction of mitochondria...
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Biochem Soc Trans (2023) 51 (1): 173–182.
Published: 23 January 2023
...Heather M. Wilkins Mitochondrial dysfunction and Aβ accumulation are hallmarks of Alzheimer's disease (AD). Decades of research describe a relationship between mitochondrial function and Aβ production. Amyloid precursor protein (APP), of which Aβ is generated from, is found within mitochondria...
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Clin Sci (Lond) (2022) 136 (24): 1851–1871.
Published: 22 December 2022
... a high level of metabolic flexibility, which is reduced in several metabolic diseases, including obesity and Type 2 diabetes (T2D). Skeletal muscle health is highly dependent on optimally functioning mitochondria that exist in a highly integrated network with the sarcoplasmic reticulum and sarcolemma...
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Biochem (Lond) (2022) 44 (4): 1.
Published: 30 August 2022
...Heather Doran Correspondence: Heather Doran ( heather.doran@dunelm.org.uk ) © Biochemical Society 2022 In this issue of The Biochemist , we are bringing you articles that cover all the things that you didn’t know about mitochondria. We all know the definition of mitochondria...
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Biochem (Lond) (2022) 44 (4): 2–8.
Published: 23 August 2022
...Ram Prosad Chakrabarty; Navdeep S. Chandel Mitochondria, special double-membraned intracellular compartments or ‘organelles’, are popularly known as the ‘powerhouses of the cell’, as they generate the bulk of ATP used to fuel cellular biochemical reactions. Mitochondria are also well known...
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Biochem (Lond) (2022) 44 (4): 22–28.
Published: 04 August 2022
...Elio Caccavale; Michael Pierre Johnson; Sonya Brijbassi; Ana C. Andreazza; Kostas Tokatlidis The ‘Mitochondria and Us’ project embodies our ambition to break new ground by working across traditionally siloed disciplines and by co-creating innovative approaches to impact research and societal...
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Biochem (Lond) (2022) 44 (4): 14–18.
Published: 01 August 2022
...Martin Picard The body and mind are fuelled by energy. But where does the energy come from? The sun beams energy through space as photons that are captured by plants, which store that energy in the improbable separation of carbon and oxygen. By reuniting carbon and oxygen in their mitochondria...
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Biochem J (2021) 478 (16): 3125–3143.
Published: 26 August 2021
...Fabian den Brave; Jeannine Engelke; Thomas Becker Mitochondria import about 1000 proteins that are produced as precursors on cytosolic ribosomes. Defects in mitochondrial protein import result in the accumulation of non-imported precursor proteins and proteotoxic stress. The cell is equipped...
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Biochem J (2021) 478 (4): 749–764.
Published: 24 February 2021
... 1 2021 © 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 cell death cocaine metabolism mitochondria oxidative stress The prevalence of cocaine abuse is increasing, with the U.K. having some of the highest rates for powder...
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Clin Sci (Lond) (2021) 135 (4): 593–595.
Published: 18 February 2021
...Shaimaa Nasr Amin This commentary highlights the research entitled: Transplantation of platelet-derived mitochondria alleviates cognitive impairment and mitochondrial dysfunction in db/db mice, presented by Ma et al. appearing in Clinical Science (2020) 134 (16), https://doi.org/10.1042/CS20200530...
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Biosci Rep (2021) 41 (1): BSR20203481.
Published: 27 January 2021
...Li-rong Yan; Ang Wang; Zhi Lv; Yuan Yuan; Qian Xu Background: Mitochondria-nuclear cross-talk and mitochondrial retrograde regulation are involved in the genesis and development of breast cancer (BC). Therefore, mitochondria can be regarded as a promising target for BC therapeutic strategies...
Includes: Supplementary data
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Clin Sci (Lond) (2021) 135 (1): 109–126.
Published: 06 January 2021
... deposition and NFTs formation in AD, such as aberrant calcium homeostasis, abnormal lipid metabolism, mitochondrial dysfunction and autophagy. Notably, these earlier pathologies are closely associated with mitochondria-associated membranes (MAMs), the physical structures connecting the endoplasmic reticulum...
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Biochem J (2020) 477 (8): 1515–1524.
Published: 29 April 2020
... ). Moreover, PolyP can stimulate F 0 F 1 -ATPase activity in the presence of ATP and, importantly, can be hydrolyzed in this enzyme instead of ATP. Furthermore, PolyP can be produced in mitochondria in the presence of substrates for respiration and phosphate by the F 0 F 1 -ATPsynthase. Thus, polyP...
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Clin Sci (Lond) (2020) 134 (7): 885–888.
Published: 14 April 2020
...Fouad A. Zouein; George W. Booz Mitochondria are dynamic, undergoing both fission and fusion. Evidence indicates that a balance between these two processes is necessary to maintain a healthy state. With ischemia/reperfusion (I/R) of the heart, fission is enhanced and is associated...
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Biosci Rep (2018) 38 (3): BSR20180208.
Published: 29 June 2018
...María Cecilia De Rossi; Valeria Levi; Luciana Bruno Molecular motors play relevant roles on the regulation of mitochondria size and shape, essential properties for the cell homeostasis. In this work, we tracked single rod-shaped mitochondria with nanometer precision to explore the performance...
Includes: Multimedia, Supplementary data
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Biochem Soc Trans (2018) 46 (2): 437–452.
Published: 27 March 2018
...Francesca Giordano Mitochondria are highly dynamic organelles involved in various cellular processes such as energy production, regulation of calcium homeostasis, lipid trafficking, and apoptosis. To fulfill all these functions and preserve their morphology and dynamic behavior, mitochondria need...
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Biochem J (2018) 475 (2): 495–509.
Published: 31 January 2018
...Inga Kruse; Andrew E. Maclean; Lionel Hill; Janneke Balk Mitochondria play a key role in the biosynthesis of two metal cofactors, iron–sulfur (FeS) clusters and molybdenum cofactor (Moco). The two pathways intersect at several points, but a scarcity of mutants has hindered studies to better...
Includes: Supplementary data
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Biochem Soc Trans (2017) 45 (4): 1025–1033.
Published: 21 July 2017
... features including the involvement of mitochondria in the mechanism of pathology and misfolding and the accumulation of abnormally aggregated proteins. Neurotoxicity of aggregated β-amyloid, tau, α-synuclein and huntingtin is linked to the effects of these proteins on mitochondria. All these misfolded...
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Clin Sci (Lond) (2017) 131 (9): 803–822.
Published: 19 April 2017
...Renée Ventura-Clapier; Maryline Moulin; Jérôme Piquereau; Christophe Lemaire; Mathias Mericskay; Vladimir Veksler; Anne Garnier It is increasingly acknowledged that a sex and gender specificity affects the occurrence, development, and consequence of a plethora of pathologies. Mitochondria...
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Biochem Soc Trans (2017) 45 (2): 477–488.
Published: 13 April 2017
...Yael Elbaz-Alon Membrane contact sites (MCSs) are areas of close apposition between the membranes of two different organelles that enable non-vesicular transfer of ions and lipids. Recent studies reveal that mitochondria maintain contact sites with organelles other than the endoplasmic reticulum...
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Biochem J (2016) 473 (23): 4457–4471.
Published: 25 November 2016
... of 280 ± 2 pS in a symmetrical 150 mM KCl solution. The mitoBK Ca channel was activated by the Ca 2+ and by potassium channel opener NS1619. The channel activity was irreversibly inhibited by paxilline, a selective inhibitor of the BK Ca channels. In isolated fibroblast mitochondria NS1619 depolarized...
Includes: Supplementary data