mitochondria

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Articles

The control of tricarboxylate-cycle xidations in blowfly flight muscle. The oxidized and reduced nicotinamide-adenine dinucleotide content of flight muscle and isolated mitochondria, the adenosine triphosphate and adenosine diphosphate content of mitochondria, and the energy status of the mitochondria during controlled respiration

R G Hansford

Biochem J (1975) 146 (3): 537–547.

https://doi.org/10.1042/bj1460537

Published: 01 March 1975

...R G Hansford 1. A study is presented of the mitochondrial NADH content during controlled (state 4) and active (state 3) pyruvate oxidation by blowfly flight-muscle mitochondria. The results confirm and extend those of an earlier study (Hansford, 1972), which indicated an increased reduction...

View article titled, The control of tricarboxylate-cycle xidations in blowfly flight muscle. The oxidized and reduced nicotinamide-adenine dinucleotide content of flight muscle and isolated mitochondria, the adenosine triphosphate and adenosine diphosphate content of mitochondria, and the energy status of the mitochondria during controlled respiration

Articles

Subcellular compartmentalization of ceramide metabolism: MAM (mitochondria-associated membrane) and/or mitochondria?

Clara BIONDA, Jacques PORTOUKALIAN, Daniel SCHMITT, Claire RODRIGUEZ-LAFRASSE, Dominique ARDAIL

Biochem J (2004) 382 (2): 527–533.

https://doi.org/10.1042/BJ20031819

Published: 24 August 2004

...Clara BIONDA; Jacques PORTOUKALIAN; Daniel SCHMITT; Claire RODRIGUEZ-LAFRASSE; Dominique ARDAIL Recent studies by our group and others have disclosed the presence of ceramides in mitochondria, and the activities of ceramide synthase and reverse ceramidase in mitochondria have also been reported...

View article titled, Subcellular compartmentalization of ceramide metabolism: MAM (mitochondria-associated membrane) and/or mitochondria?

Articles

Artifactual uncoupling by uncoupling protein 3 in yeast mitochondria at the concentrations found in mouse and rat skeletal-muscle mitochondria

James A. HARPER, Jeff A. STUART, Mika B. JEKABSONS, Damien ROUSSEL, Kevin M. BRINDLE, Keith DICKINSON, Robert B. JONES, Martin D. BRAND

Biochem J (2002) 361 (1): 49–56.

https://doi.org/10.1042/bj3610049

Published: 17 December 2001

...James A. HARPER; Jeff A. STUART; Mika B. JEKABSONS; Damien ROUSSEL; Kevin M. BRINDLE; Keith DICKINSON; Robert B. JONES; Martin D. BRAND Western blots detected uncoupling protein 3 (UCP3) in skeletal-muscle mitochondria from wild-type but not UCP3 knock-out mice. Calibration with purified...

View article titled, Artifactual uncoupling by uncoupling protein 3 in yeast mitochondria at the concentrations found in mouse and rat skeletal-muscle mitochondria

Articles

A mitochondrial membrane protein is required for translocation of phosphatidylserine from mitochondria-associated membranes to mitochondria

Young-Ji SHIAO, Bénédicte BALCERZAK, Jean E. VANCE

Biochem J (1998) 331 (1): 217–223.

https://doi.org/10.1042/bj3310217

Published: 01 April 1998

...Young-Ji SHIAO; Bénédicte BALCERZAK; Jean E. VANCE The mechanism of import of phosphatidylserine (PtdSer) into mitochondria was investigated using a reconstituted system of isolated organelles in vitro in which PtdSer was translocated from donor membranes to mitochondria and was decarboxylated...

View article titled, A mitochondrial membrane protein is required for translocation of phosphatidylserine from mitochondria-associated membranes to mitochondria

Articles

Mitochondria Revisited. Alternative Functions of Mitochondria

Dmitry B. Zorov, Boris F. Krasnikov, Alevtina E. Kuzminova, Michail Yu. Vysokikh, Ljubava D. Zorova

Biosci Rep (1997) 17 (6): 507–520.

https://doi.org/10.1023/A:1027304122259

Published: 01 December 1997

...Dmitry B. Zorov; Boris F. Krasnikov; Alevtina E. Kuzminova; Michail Yu. Vysokikh; Ljubava D. Zorova This review explores the alternative functions of mitochondria inside the cell. In a general picture of mitochondrial functioning, the importance and uniqueness of these intrinsic functions make them...

View article titled, Mitochondria Revisited. Alternative Functions of Mitochondria

Articles

The entrapment of the Ca 2+ indicator arsenazo III in the matrix space of rat liver mitochondria by permeabilization and resealing. Na + -dependent and -independent effluxes of Ca 2+ in arsenazo III-loaded mitochondria

I Al-Nasser, M Crompton

Biochem J (1986) 239 (1): 31–40.

https://doi.org/10.1042/bj2390031

Published: 01 October 1986

...I Al-Nasser; M Crompton The permeabilization-resealing technique [Al-Nasser & Crompton, Biochem. J. (1986) 239, 19-29] has been applied to the entrapment of arsenazo III in the matrix compartment of rat liver mitochondria. The addition of 10 mM-arsenazo III to mitochondria permeabilized...

View article titled, The entrapment of the Ca 2+ indicator arsenazo III in the matrix space of rat liver mitochondria by permeabilization and resealing. Na + -dependent and -independent effluxes of Ca 2+ in arsenazo III-loaded mitochondria

Articles

Rat liver mitochondria prepared in mannitol media demonstrate increased mitochondrial volumes compared with mitochondria prepared in sucrose media. Relationship to the effect of glucagon on mitochondrial function

D E Whipps, A P Halestrap

Biochem J (1984) 221 (1): 147–152.

https://doi.org/10.1042/bj2210147

Published: 01 July 1984

...D E Whipps; A P Halestrap Liver mitochondria isolated from glucagon-treated rats by using both mannitol- and sucrose-based media showed enhanced uncoupled succinate oxidation, pyruvate metabolism and citrulline synthesis. Mitochondria prepared in mannitol medium showed some stimulation...

View article titled, Rat liver mitochondria prepared in mannitol media demonstrate increased mitochondrial volumes compared with mitochondria prepared in sucrose media. Relationship to the effect of glucagon on mitochondrial function

Articles

Mitochondria 1977: Genetics and Biogenesis of Mitochondria

D. LLOYD

Biochem Soc Trans (1979) 7 (1): 258–259.

https://doi.org/10.1042/bst0070258

Published: 01 February 1979

...D. LLOYD Mitochondria 1977: Genetics and Biogenesis of Mitochondria BANDLOW W. SCHWEYEN R. J. WOLF K. KAUDEWITZ F. Walter de Gruyter Berlin and New York 1977 pp. 669, DM. 190.00 © 1979 Biochemical Society 1979 Book Reviews 258 BIOCHEMICAL SOCIETY...

View article titled, Mitochondria 1977: Genetics and Biogenesis of Mitochondria

Articles

Exchange of the Endogenous Carnitine of Ox Heart Mitochondria with External Carnitine and its Possible Relevance to the Mechanism of Fatty-Acyl Transport into Mitochondria

RONA R. RAMSAY, PHILIP K. TUBBS

Biochem Soc Trans (1974) 2 (6): 1285–1286.

https://doi.org/10.1042/bst0021285

Published: 01 December 1974

..., 1246 Thompson, E. H., Allen, C. E. & Mead, R. J. (1973) J. Anim. Sci. 36,868-873 Wahle, K. W. J. (1974) Comp. Biochem. Physiol. 48,87-106 Williams, R . B. & Mills, C. F. (1970) Brit. J. Nutr. 24, 989-1003 Exchange of the Endogenous Carnitine of Ox Heart Mitochondria with External Carnitine and its...

View article titled, Exchange of the Endogenous Carnitine of Ox Heart Mitochondria with External Carnitine and its Possible Relevance to the Mechanism of Fatty-Acyl Transport into Mitochondria

Articles

The role of mitochondria in modifying the cellular ionic environment. Calcium-induced respiratory activities in mitochondria isolated from various tumour cells

R F W Thorne, F L Bygrave

Biochem J (1974) 144 (3): 551–558.

https://doi.org/10.1042/bj1440551

Published: 01 December 1974

...R F W Thorne; F L Bygrave Cyclic stimulation by Ca 2+ of respiration in mitochondria isolated from Ehrlich ascites-tumour cells occurs only when low phosphate concentrations (approx. 0.5m m ) are also included in the incubation system. Under these circumstances the extra oxygen consumed is related...

View article titled, The role of mitochondria in modifying the cellular ionic environment. Calcium-induced respiratory activities in mitochondria isolated from various tumour cells

Articles

Biogenesis of mitochondria. The effects of altered membrane lipid composition on cation transport by mitochondria of Saccharomyces cerevisiae

J. M. Haslam, T. W. Spithill, Anthony W. Linnane, J. B. Chappell

Biochem J (1973) 134 (4): 949–957.

https://doi.org/10.1042/bj1340949

Published: 01 August 1973

...J. M. Haslam; T. W. Spithill; Anthony W. Linnane; J. B. Chappell 1. The fatty acid composition of the membrane lipids of a fatty acid desaturase mutant of Saccharomyces cerevisiae was manipulated by growing the organism in a medium containing defined fatty acid supplements. 2. Mitochondria were...

View article titled, Biogenesis of mitochondria. The effects of altered membrane lipid composition on cation transport by mitochondria of Saccharomyces cerevisiae

Articles

Biogenesis of mitochondria. A requirement for mitochondrial protein synthesis for the formation of a normal adenine nucleotide transporter in yeast mitochondria

J. M. Haslam, Margaret Perkins, Anthony W. Linnane

Biochem J (1973) 134 (4): 935–947.

https://doi.org/10.1042/bj1340935

Published: 01 August 1973

...J. M. Haslam; Margaret Perkins; Anthony W. Linnane 1. Parameters of ATP uptake by fully functional Saccharomyces cerevisiae mitochondria, including kinetic constants, binding constants and sensitivity to atractylate, closely resemble those of mammalian mitochondria. Scatchard plots of atractylate...

View article titled, Biogenesis of mitochondria. A requirement for mitochondrial protein synthesis for the formation of a normal adenine nucleotide transporter in yeast mitochondria

Articles

Protein synthesis by brain-cortex mitochondria. Characterization of a 55S mitochondrial ribosome as the functional unit in protein synthesis by cortex mitochondria and its distinction from a contaminant cytoplasmic protein-synthesizing system

A. Hernandez, I. Burdett, T. S. Work

Biochem J (1971) 124 (2): 327–336.

https://doi.org/10.1042/bj1240327

Published: 01 September 1971

.... The mitochondria–synaptosome fraction synthesized protein in vitro by a route that was partially inhibited by cycloheximide and partly by chloramphenicol. The relative effectiveness of the two inhibitors varied greatly with the medium used. In the mitochondria–synaptosome fraction active 80S cytoplasmic ribosomes...

View article titled, Protein synthesis by brain-cortex mitochondria. Characterization of a 55S mitochondrial ribosome as the functional unit in protein synthesis by cortex mitochondria and its distinction from a contaminant cytoplasmic protein-synthesizing system

Articles

Intracellular localization of enzymes in white-adipose-tissue fat-cells and permeability properties of fat-cell mitochondria. Transfer of acetyl units and reducing power between mitochondria and cytoplasm

B. R. Martin, R. M. Denton

Biochem J (1970) 117 (5): 861–877.

https://doi.org/10.1042/bj1170861

Published: 01 May 1970

... synthetase (1.0), aspartate aminotransferase (1.7), alanine aminotransferase (6.1). The mean DNA content of eight preparations of fat-cells was 109μg/g dry weight of cells. 2. Mitochondria showing respiratory control ratios of 3–6 with pyruvate, about 3 with succinate and P/O ratios of approaching 3 and 2...

View article titled, Intracellular localization of enzymes in white-adipose-tissue fat-cells and permeability properties of fat-cell mitochondria. Transfer of acetyl units and reducing power between mitochondria and cytoplasm

Articles

PROTEIN SYNTHESIS IN MITOCHONDRIA. 4. PREPARATION AND PROPERTIES OF MITOCHONDRIA FROM KREBS II MOUSE ASCITES-TUMOUR CELLS

KB FREEMAN

Biochem J (1965) 94 (2): 494–501.

https://doi.org/10.1042/bj0940494

Published: 01 February 1965

...KB FREEMAN © 1965 The Biochemical Society 1965 Biochem. J. (1965) 94, 494 Protein Synthesis in Mitochondria 4. PREPARATION AND PROPERTIES OF MITOCHONDRIA FROM KREBS II MOUSE ASCITES-TUMOUR CELLS* By K. B. FREEMAN National Institute for Medical Research, Mill Hill, London, N. W. 7 (Received 8...

View article titled, PROTEIN SYNTHESIS IN MITOCHONDRIA. 4. PREPARATION AND PROPERTIES OF MITOCHONDRIA FROM KREBS II MOUSE ASCITES-TUMOUR CELLS

Articles

Protein synthesis in mitochondria. 3. The controlled disruption and subfractionation of mitochondria labelled in vitro with radioactive valine

DB ROODYN

Biochem J (1962) 85 (1): 177–189.

https://doi.org/10.1042/bj0850177

Published: 01 October 1962

.... Smithies, 0. (1959). Advanc. Protein Chem. 16, 76. Velick, S. F. (1949). J. phys. Colloid Chem. 53, 135. Biochem. J. (1962) 85, 177 Protein Synthesis in Mitochondria 3. THE CONTROLLED DISRUPTION AND SUBFRACTIONATION OF MITOCHONDRIA LABELLED IN VITRO WITH RADIOACTIVE VALINE* BY D. B. ROODYN National...

View article titled, Protein synthesis in mitochondria. 3. The controlled disruption and subfractionation of mitochondria labelled in vitro with radioactive valine

Articles

Shaping mitochondria through fed–fast and circadian cycles

In Collection

Cell signaling in the 21st century

Subhash Khatri, Rubina Kazi, Ullas Kolthur-Seetharam

Biochem J (2023) 480 (13): 909–919.

https://doi.org/10.1042/BCJ20220378

Published: 04 July 2023

..., and hence contribute to pathophysiological states. Therefore, it is not surprising that mitochondria have emerged as being pivotal in maintaining physiological homeostasis through daily oscillations/fluctuations in nutrient inputs and light–dark/sleep–wake cycles. Moreover, given the inherent association...

View article titled, Shaping mitochondria through fed–fast and circadian cycles

Articles

New discoveries in ER–mitochondria communication

Margret Helene Bülow, Julia Sellin

Biochem Soc Trans (2023) 51 (2): 571–577.

https://doi.org/10.1042/BST20221305

Published: 09 March 2023

...Margret Helene Bülow; Julia Sellin The study of endoplasmic reticulum (ER)-mitochondria communication is a vast and expanding field with many novel developments in the past few years. In this mini-review, we focus on several recent publications that identify novel functions of tether complexes...

View article titled, New discoveries in ER–mitochondria communication

Articles

Iron and mitochondria in the susceptibility, pathogenesis and progression of COPD

Lynne Faherty, Sarah Kenny, Suzanne M. Cloonan

Clin Sci (Lond) (2023) 137 (3): 219–237.

https://doi.org/10.1042/CS20210504

Published: 02 February 2023

... that mitochondria, the central players in cellular iron utilisation, are dysfunctional in respiratory cells in individuals with COPD, with alterations in mitochondrial bioenergetics and dynamics driving disease progression. Understanding the molecular mechanisms underlying the dysfunction of mitochondria...

View article titled, Iron and mitochondria in the susceptibility, pathogenesis and progression of COPD

Articles

Interactions between amyloid, amyloid precursor protein, and mitochondria

Heather M. Wilkins

Biochem Soc Trans (2023) 51 (1): 173–182.

https://doi.org/10.1042/BST20220518

Published: 23 January 2023

...Heather M. Wilkins Mitochondrial dysfunction and Aβ accumulation are hallmarks of Alzheimer's disease (AD). Decades of research describe a relationship between mitochondrial function and Aβ production. Amyloid precursor protein (APP), of which Aβ is generated from, is found within mitochondria...

View article titled, Interactions between amyloid, amyloid precursor protein, and mitochondria

Articles

Structural functionality of skeletal muscle mitochondria and its correlation with metabolic diseases

Gourabamani Swalsingh, Punyadhara Pani, Naresh C. Bal

Clin Sci (Lond) (2022) 136 (24): 1851–1871.

https://doi.org/10.1042/CS20220636

Published: 22 December 2022

... a high level of metabolic flexibility, which is reduced in several metabolic diseases, including obesity and Type 2 diabetes (T2D). Skeletal muscle health is highly dependent on optimally functioning mitochondria that exist in a highly integrated network with the sarcoplasmic reticulum and sarcolemma...

View article titled, Structural functionality of skeletal muscle mitochondria and its correlation with metabolic diseases

Articles

Sometimes less is more: inhibitory infrared light during early reperfusion calms hyperactive mitochondria and suppresses reperfusion injury

Paul T. Morse, Junmei Wan, Jamie Bell, Icksoo Lee, Dennis J. Goebel, Moh H. Malek, Thomas H. Sanderson, Maik Hüttemann

Biochem Soc Trans (2022) 50 (5): 1377–1388.

https://doi.org/10.1042/BST20220446

Published: 06 September 2022

... restoration of blood flow is necessary to save brain tissue, it also causes reperfusion injury. Mitochondria play a crucial role in early ischemia-reperfusion injury due to the generation of reactive oxygen species (ROS). During ischemia, mitochondria sense energy depletion and futilely attempt to up-regulate...

View article titled, Sometimes less is more: inhibitory infrared light during early reperfusion calms hyperactive mitochondria and suppresses reperfusion injury

Articles

Mitochondria – expanding the role of the powerhouse

Heather Doran

Biochem (Lond) (2022) 44 (4): 1.

https://doi.org/10.1042/bio_2022_124

Published: 30 August 2022

...Heather Doran Correspondence: Heather Doran ( heather.doran@dunelm.org.uk ) © Biochemical Society 2022 In this issue of The Biochemist , we are bringing you articles that cover all the things that you didn’t know about mitochondria. We all know the definition of mitochondria...

View article titled, Mitochondria – expanding the role of the powerhouse

Articles

Beyond ATP, new roles of mitochondria

Ram Prosad Chakrabarty, Navdeep S. Chandel

Biochem (Lond) (2022) 44 (4): 2–8.

https://doi.org/10.1042/bio_2022_119

Published: 23 August 2022

...Ram Prosad Chakrabarty; Navdeep S. Chandel Mitochondria, special double-membraned intracellular compartments or ‘organelles’, are popularly known as the ‘powerhouses of the cell’, as they generate the bulk of ATP used to fuel cellular biochemical reactions. Mitochondria are also well known...

View article titled, Beyond ATP, new roles of mitochondria

Articles

Mitochondria and Us: from exploration to global collective

Elio Caccavale, Michael Pierre Johnson, Sonya Brijbassi, Ana C. Andreazza, Kostas Tokatlidis

Biochem (Lond) (2022) 44 (4): 22–28.

https://doi.org/10.1042/bio_2022_122

Published: 04 August 2022

...Elio Caccavale; Michael Pierre Johnson; Sonya Brijbassi; Ana C. Andreazza; Kostas Tokatlidis The ‘Mitochondria and Us’ project embodies our ambition to break new ground by working across traditionally siloed disciplines and by co-creating innovative approaches to impact research and societal...

View article titled, Mitochondria and Us: from exploration to global collective

Articles

Energy transduction and the mind–mitochondria connection

Martin Picard

Biochem (Lond) (2022) 44 (4): 14–18.

https://doi.org/10.1042/bio_2022_118

Published: 01 August 2022

...Martin Picard The body and mind are fuelled by energy. But where does the energy come from? The sun beams energy through space as photons that are captured by plants, which store that energy in the improbable separation of carbon and oxygen. By reuniting carbon and oxygen in their mitochondria...

View article titled, Energy transduction and the mind–mitochondria connection

Articles

Regucalcin ameliorates doxorubicin-induced cytotoxicity in Cos-7 kidney cells and translocates from the nucleus to the mitochondria

Noor A. Mohammed, Israa J. Hakeem, Nikolas Hodges, Francesco Michelangeli

Biosci Rep (2022) 42 (1): BSR20211464.

https://doi.org/10.1042/BSR20211464

Published: 06 January 2022

..., which induced membrane blebbing in some cells, the localization appeared to be correlated more with the mitochondria in these cells. It is yet to be determined whether this translocation is part of the cytoprotective mechanism or a consequence of chemically induced cell stress. Correspondence...

View article titled, Regucalcin ameliorates doxorubicin-induced cytotoxicity in Cos-7 kidney cells and translocates from the nucleus to the mitochondria

Articles

Quality control of protein import into mitochondria

Fabian den Brave, Jeannine Engelke, Thomas Becker

Biochem J (2021) 478 (16): 3125–3143.

https://doi.org/10.1042/BCJ20190584

Published: 26 August 2021

...Fabian den Brave; Jeannine Engelke; Thomas Becker Mitochondria import about 1000 proteins that are produced as precursors on cytosolic ribosomes. Defects in mitochondrial protein import result in the accumulation of non-imported precursor proteins and proteotoxic stress. The cell is equipped...

View article titled, Quality control of protein import into mitochondria

Articles

Unravelling the impact of intrauterine growth restriction on heart development: insights into mitochondria and sexual dimorphism from a non-hominoid primate

George W. Booz, Gaelle P. Massoud, Raffaele Altara, Fouad A. Zouein

Clin Sci (Lond) (2021) 135 (14): 1767–1772.

https://doi.org/10.1042/CS20210524

Published: 27 July 2021

...) mitochondria in a sex-dependent fashion with a greater effect on male fetuses, although mitochondrial transcripts increased more so in females. Increased expression for several respiratory chain and adenosine triphosphate (ATP) synthase proteins were observed. However, fetal LV mitochondrial complex I...

View article titled, Unravelling the impact of intrauterine growth restriction on heart development: insights into mitochondria and sexual dimorphism from a non-hominoid primate

Articles

Sex-dependent vulnerability of fetal nonhuman primate cardiac mitochondria to moderate maternal nutrient reduction

Susana P. Pereira, Ludgero C. Tavares, Ana I. Duarte, Inês Baldeiras, Teresa Cunha-Oliveira, João D. Martins, Maria S. Santos, Alina Maloyan, António J. Moreno, Laura A. Cox, Cun Li, Peter W. Nathanielsz, Mark J. Nijland, Paulo J. Oliveira

Clin Sci (Lond) (2021) 135 (9): 1103–1126.

https://doi.org/10.1042/CS20201339

Published: 11 May 2021

... development, predisposing offspring to cardiometabolic diseases. The role of mitochondria during fetal development on later-life cardiac dysfunction caused by maternal nutrient reduction (MNR) remains unexplored. We hypothesized that MNR during gestation causes fetal cardiac bioenergetic deficits...

View article titled, Sex-dependent vulnerability of fetal nonhuman primate cardiac mitochondria to moderate maternal nutrient reduction

Includes: Supplementary data

Articles

The role of mitochondria in cocaine addiction

Claire Thornton, Etty Grad, Rami Yaka

Biochem J (2021) 478 (4): 749–764.

https://doi.org/10.1042/BCJ20200615

Published: 24 February 2021

... 1 2021 © 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 cell death cocaine metabolism mitochondria oxidative stress The prevalence of cocaine abuse is increasing, with the U.K. having some of the highest rates for powder...

View article titled, The role of mitochondria in cocaine addiction

Articles

Platelets: the peripheral donor of mitochondria for diabetes-induced cognitive impairment

Shaimaa Nasr Amin

Clin Sci (Lond) (2021) 135 (4): 593–595.

https://doi.org/10.1042/CS20201297

Published: 18 February 2021

...Shaimaa Nasr Amin This commentary highlights the research entitled: Transplantation of platelet-derived mitochondria alleviates cognitive impairment and mitochondrial dysfunction in db/db mice, presented by Ma et al. appearing in Clinical Science (2020) 134 (16), https://doi.org/10.1042/CS20200530...

View article titled, Platelets: the peripheral donor of mitochondria for diabetes-induced cognitive impairment

Articles

Mitochondria-related core genes and TF-miRNA-hub mrDEGs network in breast cancer

Li-rong Yan, Ang Wang, Zhi Lv, Yuan Yuan, Qian Xu

Biosci Rep (2021) 41 (1): BSR20203481.

https://doi.org/10.1042/BSR20203481

Published: 27 January 2021

...Li-rong Yan; Ang Wang; Zhi Lv; Yuan Yuan; Qian Xu Background: Mitochondria-nuclear cross-talk and mitochondrial retrograde regulation are involved in the genesis and development of breast cancer (BC). Therefore, mitochondria can be regarded as a promising target for BC therapeutic strategies...

View article titled, Mitochondria-related core genes and TF-miRNA-hub mrDEGs network in breast cancer

Includes: Supplementary data

Articles

Patient-derived glioblastoma stem cells transfer mitochondria through tunneling nanotubes in tumor organoids

Giulia Pinto, Inés Saenz-de-Santa-Maria, Patricia Chastagner, Emeline Perthame, Caroline Delmas, Christine Toulas, Elizabeth Moyal-Jonathan-Cohen, Christel Brou, Chiara Zurzolo

Biochem J (2021) 478 (1): 21–39.

https://doi.org/10.1042/BCJ20200710

Published: 08 January 2021

... and in 3D-tumor organoids, formed functional TNTs which allowed mitochondria transfer. In the organoid model, recapitulative of several tumor's features, we observed the formation of a network between cells constituted of both Tumor Microtubes (TMs), previously observed in vivo , and TNTs. In addition...

View article titled, Patient-derived glioblastoma stem cells transfer mitochondria through tunneling nanotubes in tumor organoids

Includes: Multimedia, Supplementary data

Articles

Mitochondria-associated membranes (MAMs): a potential therapeutic target for treating Alzheimer’s disease

Weiwei Yu, Haiqiang Jin, Yining Huang

Clin Sci (Lond) (2021) 135 (1): 109–126.

https://doi.org/10.1042/CS20200844

Published: 06 January 2021

... deposition and NFTs formation in AD, such as aberrant calcium homeostasis, abnormal lipid metabolism, mitochondrial dysfunction and autophagy. Notably, these earlier pathologies are closely associated with mitochondria-associated membranes (MAMs), the physical structures connecting the endoplasmic reticulum...

View article titled, Mitochondria-associated membranes (MAMs): a potential therapeutic target for treating Alzheimer’s disease

Articles

Transplantation of platelet-derived mitochondria alleviates cognitive impairment and mitochondrial dysfunction in db/db mice

Hongli Ma, Tao Jiang, Wenxin Tang, Zhi Ma, Kairui Pu, Fuxing Xu, Haiqing Chang, Ge Zhao, Wei Gao, Yansong Li, Qiang Wang

Clin Sci (Lond) (2020) 134 (16): 2161–2175.

https://doi.org/10.1042/CS20200530

Published: 24 August 2020

...Hongli Ma; Tao Jiang; Wenxin Tang; Zhi Ma; Kairui Pu; Fuxing Xu; Haiqing Chang; Ge Zhao; Wei Gao; Yansong Li; Qiang Wang Diabetes-associated cognitive impairment (DACI) can increase the risk of major cardiovascular events and death. Neuronal functionality is highly dependent on mitochondria...

View article titled, Transplantation of platelet-derived mitochondria alleviates cognitive impairment and mitochondrial dysfunction in db/db mice

Includes: Supplementary data

Articles

Inorganic polyphosphate is produced and hydrolyzed in F 0 F 1 -ATP synthase of mammalian mitochondria

Artyom Y. Baev, Plamena R. Angelova, Andrey Y. Abramov

Biochem J (2020) 477 (8): 1515–1524.

https://doi.org/10.1042/BCJ20200042

Published: 29 April 2020

... ). Moreover, PolyP can stimulate F 0 F 1 -ATPase activity in the presence of ATP and, importantly, can be hydrolyzed in this enzyme instead of ATP. Furthermore, PolyP can be produced in mitochondria in the presence of substrates for respiration and phosphate by the F 0 F 1 -ATPsynthase. Thus, polyP...

View article titled, Inorganic polyphosphate is produced and hydrolyzed in F 0 F 1 -ATP synthase of mammalian mitochondria

Articles

Targeting mitochondria to protect the heart: a matter of balance?

Fouad A. Zouein, George W. Booz

Clin Sci (Lond) (2020) 134 (7): 885–888.

https://doi.org/10.1042/CS20200236

Published: 14 April 2020

...Fouad A. Zouein; George W. Booz Mitochondria are dynamic, undergoing both fission and fusion. Evidence indicates that a balance between these two processes is necessary to maintain a healthy state. With ischemia/reperfusion (I/R) of the heart, fission is enhanced and is associated...

View article titled, Targeting mitochondria to protect the heart: a matter of balance?

Articles

Natural products and phytochemical nanoformulations targeting mitochondria in oncotherapy: an updated review on resveratrol

Milad Ashrafizadeh, Sara Javanmardi, Masoumeh Moradi-Ozarlou, Reza Mohammadinejad, Tahereh Farkhondeh, Saeed Samarghandian, Manoj Garg

Biosci Rep (2020) 40 (4): BSR20200257.

https://doi.org/10.1042/BSR20200257

Published: 03 April 2020

...Milad Ashrafizadeh; Sara Javanmardi; Masoumeh Moradi-Ozarlou; Reza Mohammadinejad; Tahereh Farkhondeh; Saeed Samarghandian; Manoj Garg Mitochondria are intracellular organelles with two distinct membranes, known as an outer mitochondrial membrane and inner cell membrane. Originally, mitochondria...

View article titled, Natural products and phytochemical nanoformulations targeting mitochondria in oncotherapy: an updated review on resveratrol

Articles

Periplanetasin-4, a novel antimicrobial peptide from the cockroach, inhibits communications between mitochondria and vacuoles

Heejeong Lee, Jae Sam Hwang, Dong Gun Lee

Biochem J (2019) 476 (8): 1267–1284.

https://doi.org/10.1042/BCJ20180933

Published: 26 April 2019

...Heejeong Lee; Jae Sam Hwang; Dong Gun Lee Communications between various organelle–organelles play an essential role in cell survival. The cross-talk between mitochondria and vacuoles comes up with the vital roles of the intercompartmental process. In this study, we found a couple of cell death...

View article titled, Periplanetasin-4, a novel antimicrobial peptide from the cockroach, inhibits communications between mitochondria and vacuoles

Articles

The role of metabolism and tunneling nanotube-mediated intercellular mitochondria exchange in cancer drug resistance

In Collection

Editors' pick of review article highlights published in the Biochemical Journal in 2018 & 2019

Yalda Hekmatshoar, Jean Nakhle, Mireille Galloni, Marie-Luce Vignais

Biochem J (2018) 475 (14): 2305–2328.

https://doi.org/10.1042/BCJ20170712

Published: 31 July 2018

.... Tunneling nanotubes (TNTs) are newly discovered long-range intercellular connections that allow the exchange between cells of various cargos, ranging from ions to whole organelles such as mitochondria. TNT-transferred mitochondria were shown to change the metabolism and functional properties of recipient...

View article titled, The role of metabolism and tunneling nanotube-mediated intercellular mitochondria exchange in cancer drug resistance

Articles

Mitochondrial abnormalities in Parkinson's disease and Alzheimer's disease: can mitochondria be targeted therapeutically?

Ruby Macdonald, Katy Barnes, Christopher Hastings, Heather Mortiboys

Biochem Soc Trans (2018) 46 (4): 891–909.

https://doi.org/10.1042/BST20170501

Published: 19 July 2018

...Ruby Macdonald; Katy Barnes; Christopher Hastings; Heather Mortiboys Mitochondrial abnormalities have been identified as a central mechanism in multiple neurodegenerative diseases and, therefore, the mitochondria have been explored as a therapeutic target. This review will focus on the evidence...

View article titled, Mitochondrial abnormalities in Parkinson's disease and Alzheimer's disease: can mitochondria be targeted therapeutically?

Articles

Retraction of rod-like mitochondria during microtubule-dependent transport

María Cecilia De Rossi, Valeria Levi, Luciana Bruno

Biosci Rep (2018) 38 (3): BSR20180208.

https://doi.org/10.1042/BSR20180208

Published: 29 June 2018

...María Cecilia De Rossi; Valeria Levi; Luciana Bruno Molecular motors play relevant roles on the regulation of mitochondria size and shape, essential properties for the cell homeostasis. In this work, we tracked single rod-shaped mitochondria with nanometer precision to explore the performance...

View article titled, Retraction of rod-like mitochondria during microtubule-dependent transport

Includes: Multimedia, Supplementary data

Articles

Non-vesicular lipid trafficking at the endoplasmic reticulum–mitochondria interface

Francesca Giordano

Biochem Soc Trans (2018) 46 (2): 437–452.

https://doi.org/10.1042/BST20160185

Published: 27 March 2018

...Francesca Giordano Mitochondria are highly dynamic organelles involved in various cellular processes such as energy production, regulation of calcium homeostasis, lipid trafficking, and apoptosis. To fulfill all these functions and preserve their morphology and dynamic behavior, mitochondria need...

View article titled, Non-vesicular lipid trafficking at the endoplasmic reticulum–mitochondria interface

Articles

The fumarylacetoacetate hydrolase (FAH) superfamily of enzymes: multifunctional enzymes from microbes to mitochondria

Alexander K.H. Weiss, Johannes R. Loeffler, Klaus R. Liedl, Hubert Gstach, Pidder Jansen-Dürr

Biochem Soc Trans (2018) 46 (2): 295–309.

https://doi.org/10.1042/BST20170518

Published: 27 February 2018

... ] ( Figure 1 ). © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 In eukaryotes, nutrient-derived PYR is imported to the mitochondria where it is oxidized by the pyruvate dehydrogenase complex (PDH) to acetyl-CoA ( Figure 2A ). Acetyl-CoA enters...

View article titled, The fumarylacetoacetate hydrolase (FAH) superfamily of enzymes: multifunctional enzymes from microbes to mitochondria

Includes: Supplementary data

Articles

Genetic dissection of cyclic pyranopterin monophosphate biosynthesis in plant mitochondria

Inga Kruse, Andrew E. Maclean, Lionel Hill, Janneke Balk

Biochem J (2018) 475 (2): 495–509.

https://doi.org/10.1042/BCJ20170559

Published: 31 January 2018

...Inga Kruse; Andrew E. Maclean; Lionel Hill; Janneke Balk Mitochondria play a key role in the biosynthesis of two metal cofactors, iron–sulfur (FeS) clusters and molybdenum cofactor (Moco). The two pathways intersect at several points, but a scarcity of mutants has hindered studies to better...

View article titled, Genetic dissection of cyclic pyranopterin monophosphate biosynthesis in plant mitochondria

Includes: Supplementary data

Articles

Interaction of misfolded proteins and mitochondria in neurodegenerative disorders

Andrey Y. Abramov, Alexey V. Berezhnov, Evgeniya I. Fedotova, Valery P. Zinchenko, Ludmila P. Dolgacheva

Biochem Soc Trans (2017) 45 (4): 1025–1033.

https://doi.org/10.1042/BST20170024

Published: 21 July 2017

... features including the involvement of mitochondria in the mechanism of pathology and misfolding and the accumulation of abnormally aggregated proteins. Neurotoxicity of aggregated β-amyloid, tau, α-synuclein and huntingtin is linked to the effects of these proteins on mitochondria. All these misfolded...

View article titled, Interaction of misfolded proteins and mitochondria in neurodegenerative disorders

Articles

Mitochondria: a central target for sex differences in pathologies

Renée Ventura-Clapier, Maryline Moulin, Jérôme Piquereau, Christophe Lemaire, Mathias Mericskay, Vladimir Veksler, Anne Garnier

Clin Sci (Lond) (2017) 131 (9): 803–822.

https://doi.org/10.1042/CS20160485

Published: 19 April 2017

...Renée Ventura-Clapier; Maryline Moulin; Jérôme Piquereau; Christophe Lemaire; Mathias Mericskay; Vladimir Veksler; Anne Garnier It is increasingly acknowledged that a sex and gender specificity affects the occurrence, development, and consequence of a plethora of pathologies. Mitochondria...

View article titled, Mitochondria: a central target for sex differences in pathologies

Articles

Mitochondria–organelle contact sites: the plot thickens

Yael Elbaz-Alon

Biochem Soc Trans (2017) 45 (2): 477–488.

https://doi.org/10.1042/BST20160130

Published: 13 April 2017

...Yael Elbaz-Alon Membrane contact sites (MCSs) are areas of close apposition between the membranes of two different organelles that enable non-vesicular transfer of ions and lipids. Recent studies reveal that mitochondria maintain contact sites with organelles other than the endoplasmic reticulum...

View article titled, Mitochondria–organelle contact sites: the plot thickens

Articles

A large-conductance calcium-regulated K + channel in human dermal fibroblast mitochondria

Anna Kicinska, Bartlomiej Augustynek, Bogusz Kulawiak, Wieslawa Jarmuszkiewicz, Adam Szewczyk, Piotr Bednarczyk

Biochem J (2016) 473 (23): 4457–4471.

https://doi.org/10.1042/BCJ20160732

Published: 25 November 2016

... of 280 ± 2 pS in a symmetrical 150 mM KCl solution. The mitoBK Ca channel was activated by the Ca 2+ and by potassium channel opener NS1619. The channel activity was irreversibly inhibited by paxilline, a selective inhibitor of the BK Ca channels. In isolated fibroblast mitochondria NS1619 depolarized...

View article titled, A large-conductance calcium-regulated K + channel in human dermal fibroblast mitochondria

Includes: Supplementary data

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