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synthetic biology

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Articles
Emerg Top Life Sci (2019) 3 (5): 507–516.
Published: 23 October 2019
...Alexander A. Green Enabled by its central role in the molecular networks that govern cell function, RNA has been widely used for constructing components used in biological circuits for synthetic biology. Nucleic acid nanotechnology, which exploits predictable nucleic acid interactions to implement...
Articles
Essays Biochem (2021) 65 (5): 791–811.
Published: 02 November 2021
...Kathryn L. Garner In synthetic biology, biological cells and processes are dismantled and reassembled to make novel systems that do useful things. Designs are encoded by deoxyribonucleic acid (DNA); DNA makes biological (bio-)parts; bioparts are combined to make devices; devices are built...
Articles
Essays Biochem (2021) 65 (2): 309–318.
Published: 26 July 2021
... base for a microbial cell factory excelling in synthetic biology applications where evolution meets rational engineering. Correspondence: Suvi Santala ( suvi.santala@tuni.fi ) 26 01 2021 23 02 2021 25 02 2021 © 2021 The Author(s). Published by Portland Press Limited...
Articles
Emerg Top Life Sci (2021) 5 (5): 691–697.
Published: 23 July 2021
...Sven Epple; Afaf H. El-Sagheer; Tom Brown The modification of DNA or RNA backbones is an emerging technology for therapeutic oligonucleotides, synthetic biology and biotechnology. Despite a plethora of reported artificial backbones, their vast potential is not fully utilised. Limited synthetic...
Articles
Biochem (Lond) (2021) 43 (1): 52.
Published: 27 January 2021
...Pedro Ferreira © Biochemical Society 2021 When Mary Shelley wrote Frankenstein in 1818, she probably did not see synthetic biology coming. Shelley’s unorthodox use of galvanism and vivisection may have become computational biology, protein engineering and genome editing...
Articles
Biochem (Lond) (2020) 42 (4): 67.
Published: 07 August 2020
...Claire Price © Biochemical Society 2020 This is by no means a light-hearted scientific book or for people with only a passing interest in science. You really need to have an understanding of chemistry or biology to get to grips with this book. That being said, this book...
Articles
Biochem (Lond) (2020) 42 (4): 34–39.
Published: 29 July 2020
... for clinical evaluation. However, in recent years, an emerging synergy between synthetic biology and natural product chemistry offers the potential for a renaissance in our ability to access natural products for drug discovery and development. Advances in genome sequencing, bioinformatics and the maturing...
Articles
Biochem Soc Trans (2020) 48 (4): 1367–1378.
Published: 06 July 2020
...’ alternative to that of chemical methods, and this approach is about to undergo a renaissance thanks to synthetic biology. Synthetic biology couples molecular genetics with traditional engineering principles, incorporating a modular and standardised practice into the assembly of genetic parts. This has allowed...
Articles
Biochem Soc Trans (2020) 48 (1): 113–122.
Published: 20 February 2020
...Lionel Clarke; Richard Kitney Since the beginning of the 21st Century, synthetic biology has established itself as an effective technological approach to design and engineer biological systems. Whilst research and investment continues to develop the understanding, control and engineering...
Articles
Emerg Top Life Sci (2019) 3 (5): 631–643.
Published: 01 November 2019
...Adam M. Vogel; Kylie M. Persson; Travis R. Seamons; Tara L. Deans Synthetic biology is a relatively new field of science that combines aspects of biology and engineering to create novel tools for the construction of biological systems. Using tools within synthetic biology, stem cells can...
Articles
Emerg Top Life Sci (2019) 3 (5): 659–667.
Published: 14 October 2019
...David Tew Through the application of the engineering paradigm of ‘design–build–test–learn’ allied to recent advances in DNA sequencing, bioinformatics and, critically, the falling cost of DNA synthesis, Synthetic Biology promises to make existing therapies more accessible and be at the centre...
Articles
Emerg Top Life Sci (2019) 3 (5): 651–657.
Published: 11 October 2019
...Paul S. Freemont Synthetic biology is a rapidly emerging interdisciplinary research field that is primarily built upon foundational advances in molecular biology combined with engineering design. The field considers living systems as programmable at the genetic level and has been defined...
Articles
Emerg Top Life Sci (2019) 3 (5): 445–458.
Published: 28 August 2019
... This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and the Royal Society of Biology and distributed under the Creative Commons Attribution License 4.0 (CC BY) . bottom-up synthetic cells macromolecular crowding membrane reconstitution physicochemical...
Articles
Biochem (Lond) (2019) 41 (3): 24–27.
Published: 01 June 2019
...Lucas M. Bush; Chelsea Gibbs; Tara L. Deans Synthetic biology is a multidisciplinary field that focuses on the rational design and construction of novel genetic tools for the purpose of engineering cells to behave in controllable and predictable ways. The promise of this modern technology relies...
Articles
Biochem (Lond) (2019) 41 (3): 10–13.
Published: 01 June 2019
... but also defining the molecular mechanisms responsible. Now, we can begin to apply the approaches and techniques of synthetic biology. By re-engineering natural systems, we can hope to improve our understanding of how their components function and repurpose them for exciting biotechnological applications...
Articles
Biochem (Lond) (2019) 41 (3): 20–23.
Published: 01 June 2019
...Kalyani Kallam; Yao-Min Cai; Peter Bickerton Synthetic biology applies the principles of engineering to biology, helping us to design, redesign and build novel biological systems. First applied to microorganisms it has enabled the industrialscale production of beneficial, bio-based products...
Articles
Biochem (Lond) (2018) 40 (4): 30–31.
Published: 01 August 2018
...Corinne Hanlon The Warwick Integrative Synthetic Biology Centre (WISB) spent an amazing week interacting with visitors of all ages at the Cheltenham Science Festival from 5–10 June 2018. 2018 © Biochemical Society 2018 30 August 2018 © Biochemical Society Lifelong Learning Synthetic Biology...
Articles
Biochem (Lond) (2018) 40 (1): 47.
Published: 01 February 2018
... and act as the Society s point of contact at their institution. If you would like to get involved as an Ambassador, please contact: membership@biochemistry.org. Synthetic Biology UK 27 28 November 2017, University of Manchester, UK Synthetic biology has the capacity to transform the industrial landscape...
Articles
Biochem (Lond) (2018) 40 (1): 20–23.
Published: 01 February 2018
...Michael R. Behrens; Warren C. Ruder Synthetic biology is a relatively new research field that employs synthetic recombinant DNA technologies to engineer capabilities for addressing a wide variety of scientific and societal problems. We highlight a few noteworthy projects and achievements spanning...
Articles
Biochem Soc Trans (2017) 45 (3): 793–803.
Published: 15 June 2017
...Chris J. Myers; Jacob Beal; Thomas E. Gorochowski; Hiroyuki Kuwahara; Curtis Madsen; James Alastair McLaughlin; Göksel Mısırlı; Tramy Nguyen; Ernst Oberortner; Meher Samineni; Anil Wipat; Michael Zhang; Zach Zundel A synthetic biology workflow is composed of data repositories that provide...
Includes: Supplementary data
Articles
Biochem Soc Trans (2017) 45 (3): 781–783.
Published: 15 June 2017
...Angel Goñi-Moreno; Anil Wipat; Natalio Krasnogor The Centre for Synthetic Biology and the Bioeconomy (CSBB) brings together a far-reaching multidisciplinary community across all Newcastle University's faculties — Medical Sciences, Science, Agriculture and Engineering, and Humanities, Arts...
Articles
Biochem Soc Trans (2017) 45 (3): 585–597.
Published: 15 June 2017
...-organizing system of incredibly complex biomolecules, a marvelous dynamic that we are still attempting to unravel. Can we use what we have gleaned from biology thus far to illuminate alternative strategies for designer nanomaterial manufacturing? In the present review article, new synthetic biology efforts...
Articles
Biochem Soc Trans (2017) 45 (3): 785–791.
Published: 15 June 2017
...Simon J. Moore; James T. MacDonald; Paul S. Freemont Cell-free transcription–translation is an expanding field in synthetic biology as a rapid prototyping platform for blueprinting the design of synthetic biological devices. Exemplar efforts include translation of prototype designs into medical...
Articles
Essays Biochem (2016) 60 (4): 347–355.
Published: 30 November 2016
...Vitor B. Pinheiro; Phil Macnaghten; Richard Owen; Roland Jackson In this article we provide a short review of the debate on responsible innovation and its intersection with synthetic biology, focusing on initiatives we have witnessed and been involved with in the UK. First, we describe the ways...
Articles
Essays Biochem (2016) 60 (4): 371–379.
Published: 30 November 2016
...Vitor B. Pinheiro; Daniel Gregorowius; Anna Deplazes-Zemp Synthetic biology is an emerging field at the interface between biology and engineering, which has generated many expectations for beneficial biomedical and biotechnological applications. At the same time, however, it has also raised...
Articles
Essays Biochem (2016) 60 (4): 337–346.
Published: 30 November 2016
... desirable functions for bioindustry, such as improved genome stability, increased transformation efficacy and improved production of biomaterials. The minimal genome as a chassis genome for synthetic biology can be used to construct custom-designed genomes for various practical and industrial applications...
Articles
Essays Biochem (2016) 60 (4): 393–410.
Published: 30 November 2016
... of synthetic biology to rewrite life requires a pre-emptive strategy to tackle possible unknown risks. Physical containment barriers have proven effective but a number of strategies have been developed to further strengthen biocontainment. Research on complex genetic circuits, lethal genes, alternative nucleic...
Articles
Essays Biochem (2016) 60 (4): 381–391.
Published: 30 November 2016
... computations [ 10 ]. To date, however, no artificial single-cell-based learning system has been realised experimentally. Rapid development of synthetic biology in the previous decade has now made engineering of such a system feasible. In this review, we discuss a selection of synthetic biologists’ efforts...
Articles
Essays Biochem (2016) 60 (4): 325–336.
Published: 30 November 2016
.... Synthetic biology aims to make the engineering of biology easier, offering an opportunity to control natural systems and develop new synthetic systems with useful prescribed behaviours. However, in many cases, it is not understood how individual cells should be programmed to ensure the emergence...
Articles
Essays Biochem (2016) 60 (4): 303–313.
Published: 30 November 2016
...Vitor B. Pinheiro; Juhyun Kim; Manuel Salvador; Elizabeth Saunders; Jaime González; Claudio Avignone-Rossa; Jose Ignacio Jiménez The chassis is the cellular host used as a recipient of engineered biological systems in synthetic biology. They are required to propagate the genetic information...
Articles
Biochem Soc Trans (2016) 44 (4): 1151–1157.
Published: 15 August 2016
... the complexity and fundamentals of silk spinning, and presents arguments for establishing this substance as an interesting and important subject at the interface of systems biology (discovery) and synthetic biology (translation). It is argued that silk is a generic class of materials where each type of silk...
Articles
Biochem Soc Trans (2016) 44 (4): 1165–1175.
Published: 15 August 2016
... subset of potential chemistries. A vast amount of knowledge has been accrued through describing and characterizing enzymes, biological processes and organisms. Nevertheless, much remains to be understood about the natural world. One of the goals in Synthetic Biology is to recapitulate biological...
Articles
Biochem Soc Trans (2016) 44 (4): 1158–1164.
Published: 15 August 2016
... science goals for heavy radiation and thermal protection. Biology has the potential to solve these problems because life can replicate and repair itself, and perform a wide variety of chemical reactions including making food, fuel and materials. Synthetic biology enhances and expands life's evolved...
Articles
Biochem Soc Trans (2016) 44 (3): 723–730.
Published: 09 June 2016
...Yuval Elani The quest to construct artificial cells from the bottom-up using simple building blocks has received much attention over recent decades and is one of the grand challenges in synthetic biology. Cell mimics that are encapsulated by lipid membranes are a particularly powerful class...
Articles
Biochem Soc Trans (2016) 44 (3): 678–680.
Published: 09 June 2016
...John McCarthy Synthetic biology promises to create high-impact solutions to challenges in the areas of biotechnology, human/animal health, the environment, energy, materials and food security. Equally, synthetic biologists create tools and strategies that have the potential to help us answer...
Articles
Biochem Soc Trans (2016) 44 (3): 702–708.
Published: 09 June 2016
...Nicola J. Patron Synthetic biology aims to apply engineering principles to the design and modification of biological systems and to the construction of biological parts and devices. The ability to programme cells by providing new instructions written in DNA is a foundational technology of the field...
Articles
Biochem Soc Trans (2016) 44 (3): 689–691.
Published: 09 June 2016
...Kathleen R. Sedgley; Paul R. Race; Derek N. Woolfson BrisSynBio is the Bristol-based Biotechnology and Biological Sciences Research Council (BBSRC)/Engineering and Physical Sciences Research Council (EPSRC)-funded Synthetic Biology Research Centre. It is one of six such Centres in the U.K...
Articles
Biochem Soc Trans (2016) 44 (3): 696–701.
Published: 09 June 2016
... prostheses, incorporating living cells into life-support machines). Synthetic biology is aimed mainly at engineering cells so that they can perform custom functions: applying synthetic biological approaches to tissue engineering may be one way of engineering custom structures. In this article, we outline...
Articles
Biochem Soc Trans (2016) 44 (3): 716–722.
Published: 09 June 2016
... species including the green alga Chlamydomonas reinhardtii and the diatom Phaeodactylum tricornutum , although for both species there are bottlenecks to be overcome to allow rapid and predictable genetic manipulation. One approach to do this would be to apply the principles of synthetic biology...
Articles
Biochem (Lond) (2015) 37 (6): 38–39.
Published: 01 December 2015
...Helen Albert 2015 © Biochemical Society 2015 38 December 2015 © Biochemical Society Learning Curve Synthetic biology: hope, hype or hazard? expand the repertoire of chemical reactions available to biology. Applications of these enzymes could include DNA repair and bone regeneration. While...
Articles
Biochem (Lond) (2013) 35 (2): 54–57.
Published: 01 April 2013
...Dek Woolfson On 14 November last year, the Biochemical Society, the Royal Society of Chemistry, the think-tank BioCentre and the University of Bristol co-hosted a debate on synthetic biology, which was webcast live. Dek Woolfson co-chaired the event from Bristol. Here are his reflections...
Articles
Biochem (Lond) (2011) 33 (5): 14–18.
Published: 01 October 2011
...Lei Pei; Markus Schmidt; Wei Wei Synthetic biology (SB) is an emerging research field in China with growing interest from the scientific community and (to a much lesser extent) from the public. This interest is not only in the research itself, but also in the societal issues. This article presents...
Articles
Biochem (Lond) (2011) 33 (1): 19–25.
Published: 01 February 2011
...Derek N. Woolfson; Elizabeth H.C. Bromley A new approach in biology is emerging and gathering a broad band of advocates. Synthetic biology aims to improve our abilities to engineer biological molecules, assemblies and systems; to design and develop biomimetic systems; and to apply these to useful...
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Overview of <b>synthetic</b> <b>biology</b>  Technologies underpinning <b>synthetic</b> <b>biology</b> ...
Published: 02 November 2021
Figure 1 Overview of synthetic biology Technologies underpinning synthetic biology (bottom), disciplines using synthetic biology approaches (middle), and areas of application for synthetic biology products. Ongoing research is key to developing novel biological functions that can be exploited More
Images
Working process in <b>synthetic</b> <b>biology</b>  Making new <b>biology</b> typically follows ...
Published: 02 November 2021
Figure 5 Working process in synthetic biology Making new biology typically follows iterative cycles of Design, Build, Test, and Learn. More
Images
The ‘design-build-test-learn’ paradigm for <b>Synthetic</b> <b>Biology</b>.  <b>Synthetic</b> bi...
Published: 14 October 2019
Figure 1. The ‘design-build-test-learn’ paradigm for Synthetic Biology. Synthetic biology: the application of the ‘design–build–test–learn’ paradigm from engineering disciplines to biological systems. More
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Modified backbones for applications in therapeutics and <b>synthetic</b> <b>biology</b>. ...
Published: 23 July 2021
Figure 2. Modified backbones for applications in therapeutics and synthetic biology. Applications of artificial backbones can be divided into therapeutics and synthetic biology (top and bottom half of the circle, respectively). Yellow triangles represent reactive functional groups and yellow More
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Various methods in which <b>synthetic</b> <b>biology</b> can be used to promote the captu...
Published: 06 July 2020
Figure 2. Various methods in which synthetic biology can be used to promote the capture of metals as either metal ions (M + ) or reduced forms (M). ( A ) Absorption by an organism both on the cell surface, and intracellularly. ( B ) The addition of phytochelatins and metallothioneins More
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Recent advances in GPCR systems and <b>synthetic</b> <b>biology</b>.  ( A ) The simplifie...
Published: 23 October 2019
Figure 1. Recent advances in GPCR systems and synthetic biology. ( A ) The simplified yeast pheromone response pathway permits precise system tunability with both the native Ste2 and heterologous receptors that enables downstream sensor development. ( B) Barcoded reporters specific More
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The <b>synthetic</b> <b>biology</b> technology stack.  Reproduced from [ 21 ] with permis...
Published: 11 October 2019
Figure 2. The synthetic biology technology stack. Reproduced from [ 21 ] with permission from Will Canine CEO Opentrons. The stack is divided into four layers with the application layer being enabled by the BioCAD design layer that utilises the execution layer to deliver the design/application More