Figure 1
![The N-terminal region of human ALK (hALK) comprises two MAM domains (amino acids 264–427 and 480–626), one LDLa domain (amino acids 453–471) and a glycine rich (G-rich) region (amino acids 816–940). A transmembrane (TM)-spanning segment, connects the extracellular region with the protein tyrosine kinase (PTK), domain (amino acids 1116–1383)-containing intracellular region. The closest family member, LTK [hLTK (human LTK)], is depicted with the corresponding regions denoted. The signal peptide (amino acids 1–16), the glycine rich, G-rich, domain (amino acids 63–334) and the kinase domain (amino acids 510–777) located in the intracellular C-terminal region of the protein.](https://port.silverchair-cdn.com/port/content_public/journal/biochemj/420/3/10.1042_bj20090387/3/bj4200345fig1.jpeg?Expires=1716314486&Signature=BrSid-chWXzHSadj8QTJJtzxXvIBM1rc0w2XgBiNV4cxMvp77seaL9HcMes6ypogjUdJsXPhC1kL4JyfWnq9JgDRVLUkGLwhlbDx7NkKkt8AxfNyoMKFsrcp8Mfbyag~7cO~EDujxLVDA-TuDcinaoOPf9i1EXozU7gMCgXP3dUnkq44euqKianrZ5yrZ6FhmHypMJ1tcAP~s~TwwG-rjq341SK6my4DEnsPECAHC8PaxSr7cXzAKVjHTEPjQdDh8qmxTjdjqepN6RATIT2v~w~9bD6x01-IpDsKDaL-JUPzSOgolNn0qc80xWgmXU2iX73LJF4pGxHiM6ZEL9KxSA__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Domain structure of human ALK and human LTK
The N-terminal region of human ALK (hALK) comprises two MAM domains (amino acids 264–427 and 480–626), one LDLa domain (amino acids 453–471) and a glycine rich (G-rich) region (amino acids 816–940). A transmembrane (TM)-spanning segment, connects the extracellular region with the protein tyrosine kinase (PTK), domain (amino acids 1116–1383)-containing intracellular region. The closest family member, LTK [hLTK (human LTK)], is depicted with the corresponding regions denoted. The signal peptide (amino acids 1–16), the glycine rich, G-rich, domain (amino acids 63–334) and the kinase domain (amino acids 510–777) located in the intracellular C-terminal region of the protein.
