Figure 6.
![Amino acid sequence comparisons for each region of the six human TspanC8s were performed using the Clustal Omega multiple sequence alignment tool [57]. The average sequence identities were calculated for each region. Note that the cytoplasmic tails are even more divergent than indicated, because the sequence alignment does not factor in the different tail lengths (as indicated in Figure 4). EC1 refers to the small extracellular region and EC2 refers to the main extracellular region.](https://port.silverchair-cdn.com/port/content_public/journal/biochemsoctrans/45/3/10.1042_bst20160290/3/bst-2016-0290c_06.jpeg?Expires=1717075885&Signature=OT6lgHi4VwhHbZVLlRVcdfIcg7OQecc~6rkXrOFvqBx9JnLqrNUkuo8Aa8BS8Pozr9t4Q0RryWDSLJG6Ng2wy9cxQopJMsuSrA0UprWZjLI~c4luKSIKM2yHyZ2OT5n0yOpNkeJ-poU85W3Rq2ZK~oDY1Fy6b54rw9e2iLV1Cu-lIp5HpuExd~bxfVJo2UIisg8Nfa8Lo4TsRSGMxKp25-y5MEMNmuU2fSwxMpy4utmsCUN5EbfSaplzEoKO2qHuNhfnIX6jJ59EXMMprSvU~GWBwE8NxxLWIlOq1nxl6bzA1nN~Z0VG0iVH5rlIaaELDdCKhhHkzVZ~qdlM-yPGmg__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
The variable region of the main extracellular domain is the most highly conserved region of TspanC8s, and the cytoplasmic tails are the least conserved.
Amino acid sequence comparisons for each region of the six human TspanC8s were performed using the Clustal Omega multiple sequence alignment tool [57]. The average sequence identities were calculated for each region. Note that the cytoplasmic tails are even more divergent than indicated, because the sequence alignment does not factor in the different tail lengths (as indicated in Figure 4). EC1 refers to the small extracellular region and EC2 refers to the main extracellular region.
